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Pharmacotherapeutics > Adverse Effect Of Medications > Flashcards

Adverse Effect Of Medications Flashcards

1
Q

Amino glycosides

A

Ototoxicity
Nephrotoxicity

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2
Q

Tetracyclines

A

Photosensitivity
Tooth discoloration
Esophageal irritation
Intracranial hypertension

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3
Q

Bisphosphonates

A

Eosophageal irritation
Hypophosphotemia
Osteonecrosis of the jaw
Atypical femoral fracture

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4
Q

Cyclophosphamide ifosfamide

A

Hemorrhagic cystitis

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5
Q

PDE5 inhibitors

A

Hypotension
Tachycardia
Nasal congestion
Headache
Dizziness

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6
Q

Statins

A

Rhabdomyolysis
Diabetes
Elevated liver enzymes

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7
Q

Lamotrigine

A

Skin rash

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8
Q

Isoniazid’s

A

Pyrodoxine deficiency
Peripheral neuropathy
Hepatotoxicity

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9
Q

Amiodarone

A

Pulmonary toxicity
Thyroid abnormalities
Blue-Gray skin discoloration
Phototoxicity
Corneal microdeposits

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10
Q

Vancomycin

A

Ototoxicty
Hepatotoxicity
Red man’s syndrome
Nephrotoxicty
Blood disorder-thrombocytopenia

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11
Q

Quinine

A

QT prolongation
Deafness
Blindness
Conchonism

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12
Q

Flouroquinolones

A

Tendon rupture
QT prolongation
lowering seizure threshold

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13
Q

Corticosteroids

A

Osteoporosis
Steroid-induced diabetes
Mood/ behavioral
Hypertension, hypokalemia
Edema
Immunosuppression

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14
Q

Opiods

A

Constipation
Euphoria
Respiratory depression
Itch
Pupillary depression

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15
Q

Metformin

A

Weight loss
Lactic acidosis
Vitamin B12 deficiency
Gastrointestinal upset

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16
Q

Trimethoprim

A

Gastrointestinal upset
Hyperkalemia
Elevated creatinine levels
Megaloblastic anemia

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17
Q

Phenytoin

A

Gingival enlargement
Hirsutism
Osteomalacia
Skin coarsening / acne
Nystagmus / ataxia
Purple glove syndrome

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18
Q

ACE inhibitors

A

Persistent, dry cough
Hyperkalemia
Hypotension
Renal failure

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19
Q

Aspirin

A

Bleeding
Stomach ulcers
Reye syndrome (under 16s)
Tinnitus (high doses)

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20
Q

Iron supplements

A

Black stools

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21
Q

Bismuth subgallate

A

Black tongue, black stools

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22
Q

Amphotericin B

A

‘Shake and bake’ reaction
Hypokalemia
Myocarditis
Hepatotoxicity
Kidney damage

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23
Q

Lithium

A

Hypothyroidism
Diabetes type 2
Kidney damage
Weight gain
Myoclonus

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24
Q

Clofazimine

A

Hyperglycemia
Brown-pink skin discoloration
Skin dryness, rash

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25
Q

Ethambutol

A

Red-green colourblindness
Optic neuritis
Hepatotoxicity
Peripheral neuropathy
Hyperuricemia

26
Q

Clozapine

A

Agranulocytosis
Myocarditis
Hypersalivation
CNS effects
Urinary incontinence
GI hypomotility
Bone marrow suppression

27
Q

SSRIs

A

Weight disturbance
Gastrointestinal upset
QT prolongation
Hyponatremia
Bone fractures
Serotonin syndrome
Lower seizure threshold

28
Q

Antimuscarinics

A

Tachycardia
Dry mouth
Blurred vision
Urinary retention
Constipation
Drowsiness

29
Q

Beta-2 agonists

A

Tachycardia
Palpitations
Anxiety
Tremors
Muscle cramps
Hypokalemia
Sweating
Insomnia
Agitation

30
Q

Typical antipsychotics

A

Extrapyramidal side effects
QT prolongation
Sexual dysfunction

31
Q

Atypical antipsychotics

A

Weight gain
Diabetes type 2
Lipid abnormalities
Extrapyramidal effects

32
Q

Benzodiazepines

A

Drowsiness, sedation
Respiratory depression
Amnesia
Decreased concentration

33
Q

NSAIDs

A

Gastrointestinal bleeding
Renal impairment
Fluid retention
Photosensitivity

34
Q

Beta blockers

A

Bronchospasm
Vivid dreams / nightmares
Cold extremities
Hypoglycemia

35
Q

Methimazole

A

Agranulocytosis

36
Q

Calcium channel blockers

A

Constipation
Gingival overgrowth
Ankle swelling
Flushing

37
Q

Rifampin

A

Hepatotoxicity
Red urine, sweat, tears

38
Q

Methotrexate

A

Hepatotoxicity
Ulcerative stomatitis
Infections
Pulmonary fibrosis

39
Q

Irinotecan

A

Extreme diarrhea

40
Q

Cisplatin

A

Hearing loss
Kidney damage
High risk of vomiting

41
Q

Flucytosine

A

Bone marrow suppression
Loss of appetite
Psychosis
Renal damage

42
Q

Macrolides

A

QT prolongation
GI effects
Ototoxicity (high doses)
Cholestatic jaundice

43
Q

Heparin
Warfarin
Antiplatelets
Anticoagulants

A

Bleeding
Thrombocytopenia (heparin)

44
Q

Levothyroxine

A

Weight loss
Trouble sleeping
Tachycardia
Anxiety
Difficulty tolerating heat
Palpitations

45
Q

Thalidomide

A

Phocomelia / limb deformities

46
Q

Carmustine
Busulfan

A

Pulmonary toxicity

47
Q

Iron dextran

A

Severe anaphylaxis

48
Q

Capecitabine

A

Hand-foot syndrome

49
Q

Tamoxifen

A

Uterine cancer
Pulmonary embolism
Reduced cognition
Irregular periods
Hot flashes

50
Q

Nitrates

A

Flushing
Headache
Light-headedness
Hypotension

51
Q

Nitrofurantoin

A

Gastrointestinal upset
Pulmonary fibrosis
Brown discolored urine
Peripheral neuropathy
Elevated liver enzymes
Hemolyticanemia

52
Q

Thiazolidinediones

A

Anemia
Dizziness, headache
Edema
Bladder cancer
Bone fractures
Hepatotoxicity

53
Q

Valproate

A

Gastrointestinal upset
Tremor, ataxia, behavioral effects Increased liver enzymes Thrombocytopenia
Hair loss
Pancreatitis

54
Q

Itraconazole

A

Vision disturbances
Heart failure
Skin rash
Hepatotoxicity

55
Q

Linezolid

A

Thrombocytopenia
Peripheral neuropathy
Serotonin syndrome

56
Q

Metronidazole

A

Metallic-like taste
Seizures
Thrombophlebitis (IV use)
Dark urine
Peripheral / optic neuropathy Encephalopathy (high doses)
Disulfiram-reaction (with alcohol)

57
Q

Loop diuretics

A

Dehydration
Hypotension
Low electrolyte state
Hearing loss / tinnitus (high doses) Kidney failure (w/ NSAID + ACE inhibitor) Hyperuricemia

58
Q

Aldosterone
antagonists

A

Gynecomastia
Hyperkalemia

59
Q

Allopurinol

A

Skin rash, sometimes SJS/TEN Hypersensitivity reaction
Bone marrow suppression

60
Q

Colchicine

A

Rhabdomyolysis
Bone marrow suppression
Gastrointestinal upset

Pharmacotherapeutics (13 decks)

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