AE effects - Adrenergic Flashcards
(16 cards)
α-Methyltyrosine
Drowsiness,
depression,
diarrhea,
nightmares
α-Methyldopa
Drowsiness,
xerostomia
Reserpine
Extreme sedation,
severe depression,
diarrhea,
nasal congestion
Amphetamine
↑BP ↑HR cardiac arrhythmias Insomnia headaches nervousness
Ephedrine
↑BP,
↑HR (especially with ephedrine)
Insomnia
nervousness (especially with ephedrine)
TCA’s
mAChR antagonist (anticholinergic) adverse effects:
Dry as a bone
Mad as a hatter
Blind as a bat
α1 antagonist adverse effects:
Ortho HoTN
H1 antagonist adverse effects: drowsiness ↑appetite → weight gain Cardiac arrhythmias conduction delays, etc
MAO-I’s
Hypertensive crises following ingestion of tyramine-containing foods
NE & EPI
↑HR
cardiac arrhythmias
HTN
Phenylephrine
↑BP
When used for nasal congestion, rebound hyperemia and rhinorrhea following discontinuation after prolonged administration (rhinitis medicamentosa)
Clonidine
Drowsiness
xerostomia
sexual dysfunction
Phentolamine
Orthostatic HoTN
Reflex tachyC
Prazosin & Tamsulosin
Orthostatic HoTN
Reflex tachyC
Isoproterenol
TachyC
cardiac arrhythmias
angina pectoris (especially in patients with underlying cardiac disease)
Dobutamine
TachyC
cardiac arrhythmias
Albuterol
Tremor (SKM) Anxiety Apprehension TachyC Cardiac arrhythmias (overdose)
Beta Blockers
HF,
BradyC
AV block
Exacerbation of asthma or COPD
Impairment of peripheral circulation (esp w non selective)
↑Risk of hypoglycemic unawareness and hypoglycemic episodes in patients with DM
↑Risk of angina pectoris,
MI
cardiac arrhythmias
sudden death following abrupt discontinuation
Adverse metabolic effects (dec HDL, ↑TGs)
Vivid dreams
Fatigue
drowsiness
Sexual dysfunction
