AE effects - Adrenergic Flashcards Preview

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Flashcards in AE effects - Adrenergic Deck (16):
1

α-Methyltyrosine

Drowsiness,
depression,
diarrhea,
nightmares

2

α-Methyldopa

Drowsiness,
xerostomia

3

Reserpine

Extreme sedation,
severe depression,
diarrhea,
nasal congestion

4

Amphetamine

↑BP
↑HR
cardiac arrhythmias
Insomnia
headaches
nervousness

5

Ephedrine

↑BP,
↑HR (especially with ephedrine)
Insomnia
nervousness (especially with ephedrine)

6

TCA's

mAChR antagonist (anticholinergic) adverse effects: xerostomia
urinary retention (esp w BPH)
constipation
confusion
drowsiness
attacks of angle-closure glaucoma in susceptible patients, etc

α1 antagonist adverse effects:
Ortho HoTN

H1 antagonist adverse effects:
drowsiness
↑appetite → weight gain
Cardiac arrhythmias
conduction delays, etc

7

MAO-I's

Hypertensive crises following ingestion of tyramine-containing foods

8

NE & EPI

↑HR
cardiac arrhythmias
HTN

9

Phenylephrine

↑BP
When used for nasal congestion, rebound hyperemia and rhinorrhea following discontinuation after prolonged administration (rhinitis medicamentosa)

10

Clonidine

Drowsiness
xerostomia
sexual dysfunction

11

Phentolamine

Orthostatic HoTN
Reflex tachyC

12

Prazosin & Tamsulosin

Orthostatic HoTN
Reflex tachyC

13

Isoproterenol

TachyC
cardiac arrhythmias
angina pectoris (especially in patients with underlying cardiac disease)

14

Dobutamine

TachyC
cardiac arrhythmias

15

Alburterol

Tremor (due to stimulation of β2 receptors on SKM)
CNS effects: anxiety, apprehension
Cardiac stimulation including tachycardia (β2 agonists are not 100% selective for β2 receptors)
Cardiac arrhythmias (overdose)

16

Beta Blockers

HF,
BradyC
AV block
Exacerbation of asthma or COPD
Impairment of peripheral circulation (esp w non selective)
↑Risk of hypoglycemic unawareness and hypoglycemic episodes in patients with DM
↑Risk of angina pectoris,
MI
cardiac arrhythmias
sudden death following abrupt discontinuation after chronic use, esp w coronary dz
Adverse metabolic effects (dec HDL, ↑TGs)
Vivid dreams
Fatigue,
drowsiness
Sexual dysfunction