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Flashcards in Ageing process Deck (10)
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1
Q

What is ageing

A

progressive, generalised impairment of function resulting in a reduction of the body’s adaptive response to disease

2
Q

What are some causes of ageing

A

Random molecular damage during cell replication
Poor diet, inactivity, inflammation
Loss of resilience (ability to adapt to disease)

3
Q

Where are telomeres found

A

The ends of chromosomes

4
Q

What is the Hayflick limit

A

The number of times a cell can divide before it stops cell division altogether

5
Q

What are the cellular responses to damage

A

Repair
Apoptosis
Senescence
Malignant transformation

6
Q

Describe frailty

A

Loss of homeostatic balance and resilience

7
Q

What are the 2 methods of measuring frailty

A

Phenotypic

Deficit accumulation

8
Q

How is frailty measured phenotypically

A
1 point for each: 
unintentional weight loss 
self reported exhaustion 
low grip strength 
low physical activity 
slow walking speed 
>3 = frailty
9
Q

How is frailty measured by deficit accumulation

A

take a large number of body systems and count how many of those systems have a deficit
Calculate deficits/systems
value between 0-1
closer to 1 is more frail

10
Q

Positive lifestyle factors that increase survival in old age

A

Balanced diet
Not smoking
physical activity
friends