Agents for Infections of GI tract (Segars) Flashcards
Treatment of H. Pylori is always :
Typical regimen is:
2 antibiotics + acid reducer (PPI)
- PPI (-prazole)
- Clarithromycin
- Amoxicillin or Metronidazole
When would we consider quadruple therapy for H. Pylori?
community resistance or recurring H. Pylori inf.
What does Quadruple Therapy for H. Pylori entail?
–A PPI (‘-prazole’)
–Metronidazole
–Amoxicillin(Tetracycline; esp. for PCN allergy)
–Bismuth subsalicylate
•Can substitute Clarithromycin for bismuth
•Can substitute Levofloxacin for failed eradication
Dosing for H. Pylori eradication regimen?
PPI BID x14 days (longer if ulcer is unresolved)
Abx QID x14 days
What would you prescribe for treatment of Clostridiodes difficile?
Vancomycin (ORAL)
alternative: Fidaxomicin
What would you prescribe a very sick pt in ICU with C. diff infection?
IV Metronidazole (for severe disease) + oral Vanco.
What would you prescribe for pt with campylobacer jejuni?
Azithromycin
alt: ciprofloxacin
What would you prescribe for pt with salmonella spp?
Ciprofloxacin/levofloxacin
alt: azithromycin
What would you prescribe for pt with shigella spp?
ciprofloxacin/levofloxavin
alt: azithromycin
Antihelmintics common drug naming convention
Benzimidazoles
Albendazole
Mebendazole
Anti-protozoals naming convention?
Paromomycin
Metronidazole
Tinidazole
Paromomycin MOA
binds to receptors on 30S ribosomal subunit (interferes with DNA synth)
Metronidazole & Tinidazole MOA
has antibacterial and anti-protozoal activity
passive diffusion into organism, creates free radicals, inhibits DNA synth and induces DNA degradation
What would you prescribe for pt with Entamoeba histolytica?
(amebiasis)
Metronidazole
What would you prescribe for pt with Ancylostoma spp?
(hookworm)
Albendazole
