Agents for Sickle Cell Anemia

Question 1

Agents for Sickle Cell Anemia: Name

Answer 1

Hydroxyurea

Question 2

Agents for Sickle Cell Anemia: Actions and Indications

Answer 2

◦Increases amount of fetal hemoglobin produced in bone marrow◦Dilutes formation of the abnormal hemoglobin S

Question 3

Agents for Sickle Cell Anemia: Contraindications

Answer 3

Contraindications:
◦Known allergy
◦Severe anemia or leukopenia

Question 4

Agents for Sickle Cell Anemia: Cautions

Answer 4

Caution:
◦Impaired liver or renal function
◦Pregnancy and lactation

Question 5

Agents for Sickle Cell Anemia: Adverse Effects

Answer 5

◦GI effects, skin rash or erythema, and bone marrow depression, increased cancer risk

Question 6

Agents for Sickle Cell Anemia: Drug Interactions

Answer 6

◦Uricosuric agents