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Agents infectieux facteur de virulence Flashcards

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1
Q

VP4, VP7 = attachement

A

Rotavirus (RNA non E)

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2
Q

NSP4 (enterotixin)

A

Rotavirus RNA non E

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3
Q

Glycoprotein G binds LDL-R
targets squamous epithelium

A

Arbovirus (RNA E)

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4
Q

Glycoprot E1, E2 attache crypt
Lysis PP, necrosis vascular wall

A

BVD (pestivirus, RNA, E)

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5
Q

Target CD150 (lympho)
SLAM

A

Rinderpest (morbili RNA E)

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6
Q

FIL attache heparan-R
synthesis VEGF = angiogenesis

A

Parapox DNA E
Echtyma contagieux

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7
Q

VP1 à 4 attache
R-integrin VB1-3-6

A

Aphtovirus RNA non E
Foot and mouth dz

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8
Q

S prot binds sialic acid in mucus layer
E2 = entry

A

Coronavirus RNA E
GIT

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9
Q

VP14 attache
R=ICAM

A

Enterovirus RNA non E
swine vesicular dz

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10
Q

tropisme endothelial cell -> CIVD

A

Calicivirus RNA non E
exanthème Fe

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11
Q

Need duplex transcription template = only in S phase
R= transferrin (Ca)
R = transferrin, neuraminic acid (Fe)

A

Parvovirus DNA non E

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12
Q

Lysis epithelial/endothelial cells
Fiberprotein = attache
R-integrin (coxackievirus-adenovirus)

A

Phlebovirus DNA non E
Rift valley

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13
Q

HA = entry
NA = shedding
HA/NA bind to target sialligosaccharide

A

Orthomyxovirus RNA E
Influenza Eq

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14
Q

Glycoprot B, C, D = attache
Mediator A, nectin 1-2, 3-0 sulfate heparin = entry
Trigeminal/olfactive nerve (retrograde axonal)
Active by multiplication by axonal transport to mucosa and going into epithelial cells

A

Herpesvirus DNA E
IBR

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15
Q

What does latent virus mean?

A

Latent = NO CMH II. LOW CMH I = less CTL, macro
Virus in nucleus without protein synthesis

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16
Q

Glycoprotein G = attache
Glycoprotein F = fusion
TLR3-4 for inflamm

A

Pneumovirus RNA E
syncitial

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17
Q

Infects monocytes precursors in bone marrow = reservoir
Genome inserted on chromosomal DNA = persiste infection
Chronic inflamm lung, brain, mammary, synovial, demyelinating encephalitis

A

Lentivirus RNA E
Maedivisna

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18
Q

R = Sialoadhesin, CD163, heparan
Acute inflamm mucociliary -> bact infection

A

Arterivirus RNA E
SRRP

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19
Q

Infect injure erythroid precursors
= neonatal anemia

A

Herpesvirus (cytomegalovirus) DNA E
inclusion body rhinitis

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20
Q

PAS CONTAGIEUX
bite from midges
Capside VP2, VP5, NS3 (insertin)
Cytotoxin (viroporin)
Source = semen accessory glands

A

Orbivirus RNA non E
African horse sickness

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21
Q

Lysis vascular endothelium
Lysis lymphocytes
Vasculitis
Dead-end host because spread need free cell virus = don’t exist

A

Gammaherpesvirus DNA E
fièvre catarrhale maligne

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22
Q

Erns, E2 envelop, glycoprotein

A

Pestivirus RNA E
Classical swine fever

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23
Q

Envelop glycoprot = p12, p54, p30

A

Asfivirus DNA E
African swine fever

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24
Q

Glyco = B, C, D
basse temperature helps

A

Canine herpesV type I

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25
Antigenic shift/drift of 3c genes in mucosal macrophages S1, S2, M, E = attache
PIF
26
What is the immune response in PIF? SC?
HIGH cell mediated = no PIF LOW cell mediated = dry NO cell mediated = wet effective HUMORAL = more severe Adequate AC = hyperS III -> complement => neutro Type 4 in some pygranulomas
27
envelop gp120, gp90 R-lentivirus-R-1 Cell free vitus act as hapten on RBC -> phagocyte + présente lympho -> humoral response -> hyperSe II What happens if haptens active complement?
Lentivirus Anemie infectieuse equine (bloodborne) active complement = RBC lysis
28
Changement LB (gene transactivation) Provirus infected LT gp51, gp30 enter naive LB = express IgM CD5, CD11b = susceptible infection p34tax = prolif LB = X virus + growth/differenciation
Deltavirus Leukemia Bo
29
Need S phase X Macro non permissive Lympho permissive
Circovirus 2
30
LB spread virus LT = #1 target Need fast dividing cells Persistent LT infection = clinical signs Surface Su, TM
Retrovirus Leukemia Fe
31
infect CD4+ SU, TM Target CD134, CXCR4
Lentivirus FIV
32
Dysrupt neurotransmitter fct Gprot -> NT-R -> Muscle -> X -> interstitial bind acetylcoA, ganglioside -> retrograde (dynein) -> nerfs 7 (facial), glossopharyngien (9)
Lyssavirus rabies
33
dysfct endo cell of arterioles in brain + spinal cord immune complex
alphaherpesvirus encephalite equine
34
Target neurons cell bodies +++ CTL, retrograde axonal
alphaherpes Pseudorabies
35
viral H prot + fusion protein F R = CD150 (SLAM)
Distemper Morbilivirus
36
NS1 produced by virus = TOXIC
Feline parvovirus cerebral hypoplasia
37
dysfct gene prolif/diff/adhesion Integrin a6B4 - heparan sulfate = attache Bovine L1, L2 capside basal cell = non permissive = reservoir = X genome virus mature on the way to upper layer = complete cycle what does it mean if the cell doesn't go into the target cell? if integrate in suprabaal layer)
Viral papilloma warts, sarcoids NO = benign (no permissive) upper = malin (permissive)
38
Action of E5
active R-PDGF, EGF inhibe CMH I
39
action E6
Inhibe p53, BAK active telomerase, BCL2, mTOR, MYC
40
action E7
Active HIFa baisse Rb, p21 favorise bris DNA
41
only between cats persistent infection of MO (LT precursor) = baisse immun cell mediated = baisse CTL, baisse IFNy, IL secreted by LT, dysfct neutro/macro R = feline thiamine transport protein
FeLVA
42
Shift recombination of type A neoplastic change R = feline phosphate transporter protein 1-2
FeLV B
43
Point mutation (antigenic drift) anemia R = FeLVCR
FeLVC
44
Infects LT = immunosuppressive syndrome R = FePIT1
FeLVT
45
Secreted by LT = restrict tropism to LT
FeLVX
46
caracteristic of reovirus (FeLV)
produce reverse transcriptase (reo) to transcribe viral RNA into proviral DNA = insertion chromosome LT
47
Where is FOCMA expressed in FeLV
expressed on cell membrane of changed cells NOT on infected or not transformed cell
48
Type 1 fimbriae, S, P bind uroplakin-R
UPEC
49
K99, F41 LT = cAMP, ST = cGMP = irreversible opening of chlore channel
ETEC
50
EspA, EspB, EspD, intimin fimbriae S, P
EPEC
51
Verotoxin, shigatoxin
EHEC
52
LPS, tue macro type 1 secretory system = caspase 1, apopto
Salmonelle
53
PA (B) = entry EF = dysrupt membrane (ATP -AMPc) LF = destroy MAPK = cell death
anthrax
54
Vaps
R.equi
55
Iron chelating prots (exochelin, siderophore, iron reductase) Mannonse-BR on macro + CD14 = NO CYTOKINE
M.avium pseudotuberculosis Johne
56
LsaA= entry Escape phagocome reste IC for X
Lawsonia
57
Hemolysn, protease, hausse mucus
B, hyodysentariae
58
Kupffer cell, phospholipase C, hemolysin
C.haemolyticum
59
SzP (Mlike prot), determine organe C5a peptidase, invasin, fibronectin BP = biofilm
Strep equi zoo
60
CR1-3-4, MannoseR, CD14 waxy cell wall
Mbovis
61
Apx1-111 = pore
A. pleuropneumoniae
62
DNT, hemolysine -> squamous metaplasia PMT = block osteoblast
Bbronchi Pmulto
63
Block fusion phagocyte LPS, cyclic B-1,2 glucan, HSP
Brucella
64
SeM, SzPSE = adhesin SeeH = macro Streptokinase (plasminogen -> plasmin ->baisse fibrine) Streptolysin S = pore
Strep equi equi
65
Internalin A, B via e-cadherin Listeriolysin O (baisse immune, hausse prolif) Act A = propel
Listeria monocytogenes
66
Adhesion factor 1 to CR3 CD14 (alveolar macro)
Blastomycosis
67
Enters via MBL and CR3 = block phago formation reconnu par TLR2 (lipoarab), TLR9 (CpG) -> IFNy -> defensin -> autophagy -> NO
Tuberculosis
68
Recognized by TLR2, lectin-dectin reconnait 1-3-B glucan in cell wall
Aspergillus
69
Lypophosphoglycan -> glycocalyx active complement sans MAC, opsonize C3 binds MAC-1 + CR1 Gp63 = cleave complement
Leishmania
70
Dx cell in mitosis
Ki67 PCNA AgNOR
71
Dx cell in apoptosis
caspase annexin TUNEL

Nutrition (13 decks)

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