Agents used in cardiac arrhythmias Flashcards
(24 cards)
Ivabradine MoA
Selective inhibition of funny channels in SA node, to slow its firing , and ↓HR
(Prolong the drift)
Two adverse effects of Ivabradine
Bradycardia
Visual disturbance
What is the mechanism of action of class one drugs
Modulate or inhibit sodium channels prolong phase 0
What is the mechanism of action of Quinidine Ia
Sodium channel blocker slow activation (firing)
Potassium channel blocker (Prolongs action potential)
Adverse effects of Quinidine
Conduction disturbance (slow) Pro arrhythmia and ventricular arrhythmia Hypotension Hypoglycemia NV Cinchonism Immune-mediated reactions 
Mechanism of action of Lidocaine
Sodium channels blockade (Phase 3 shortens repolarization) + K (weak)
Have central nervous system effects
Mechanism of action of Flecainide 
 sodium channel blocker
Potassium channel blocker
Slows phase zero
Adverse effects of Flecainide
Malignant arrhythmia (use only fir healthy hearts)
Dizziness, blurred vision, headache
What are the class two drugs
Propranolol
Sotalol
B1 blockers
Where is the mechanism of action of class two drugs
They inhibit the sympathetic activity
What are the class three drugs and their mechanism of action
Amiodarone
Potassium channel blocked
Prolongs the repolarization phase (phase 3)

What are the adverse effects of amiodarone
Pulmonary toxicity Thyroid dysfunction Bradycardia AV block QT PRONLONGATION Hepatitis Skin reaction blue man syndrome photosensitivity Tear deposits
What is the mechanism of action of verapamil
Ca+ Channel blocker slows firing
Quinidine + Procainamide
Na channel blockade
Depress phase 0 depolarization Slows conduction
K channel blockade
Prolongs action potential duration “APD” and ↑ERP
Sites: As+Vs
Clinical uses of Amiodarone
atrial arrhythmias
paroxysmal atrial fibrillation
pharmacologic cardioversion of AF
Prevention of postoperative atrial fibrillation and atrial flutter
Prevention of implantable cardioverter defibrillator (ICD) shocks
Secondary prevention of sudden cardiac death
Adverse effects of Amiodarone
Pulmonary toxicity (pneumonitis)
Thyroid dysfunction
Cardiac toxicity; bradycardia, AV blocks, QT prolongation
Hepatitis
Skin reactions: photosensitivity or blue-man syndrome
Corneal micro-deposits
Ivabradine class 👙
hyperpolarization-activated cyclic nucleotide-gated channels blocker
What drug causes QTprolongation
Quinidine
What drugs have a hypotension effect working on A adregenic receptor
Quinidine
Drug that shortens phase 3 repolarization (Atrium, Ventricle)
Lidocaine
What drugs markedly slow phase 0 depolarization
Flecainide
What drug prolong phase 4 repolarization (Atrium Ventricle)
Amiodarone
What drug causes dry cough
Amiodarone
Verapamil and diltiazem moa
Slows phase 4 SA AV
