Alcohol Metabolism Flashcards
Ethanol effect of NADH
INcreases NADH/NAD+ ratio
- increase lactate/pyruvate
- INhibits gluconeogenesis/lysus
- Inhibits FA ox
tricks body to thinking it is in high energy state so all energy creating pathways are blocked
Small/Med alcohol effect on body (3+mechs)
NADH accumulation-
energy depletion
-PDH inhibited=lactic acidosis
-TCA cycle inhibited
Hypoglycemia
-gluconeogen and glycolysis is inhibited
Incerased acetyl CoA formation
- FA syn accelerated
- Ketone body fomration accelerated=Ketoacidosis
Only time when ketoacidosis and FA syn occur at same time (i think)
Ethanol NADH effects (4)
block conversion of cytoplasmic malate to oxaloacetate-preventing gluconeogen
Glyceraldehyde 3 P DH runs backwards-glycolysis is inhibited
Lactate dehydrgoeanse inhibited=no conversion of lactate to pyruvate
Severe hypoglymica possible
Acetaldehyde
Metabolite of alcohol
Peripheral dialtor-vessel near skin surface enlarge-flushing of face, headache, nasuea, vomiting etc.
THE ONE YOU DONT WANT
ALDH 1 vs ALDH2
ALDH1 better at converting Acetaldehyde to acetate
-much faster reaction-metabolize more in less time vs ALDH2
ALDH better than ALD
-acetaldehyde is shiity want less
ALDH2 worse at converting acetaldehye to acetate
-Acetaldehyde accumulation
CYP2E1
MEOS overflow pathway
Uses NADPH and oxygen
Makes NADP, water, and acetaldehyde
metabolizes acetaldehyde, acetaminophen, isoniazid, phenobarbital (barbituate)
- these all compete=will have less excretion/breakdown of drug
- drug and its metabolites can interact with CNS
CYP2E1 and NAPQ1
W/O alchol-Cyp activity low
Cyp metabolizes tyelenol to toxic intermediate=NAPQ1
- detox and excreted radidly
- if @ heavy drinker=more CYP-more NAPQI produced-liver toxicity
