Alcoholic Hepatitis Flashcards
(31 cards)
What is the marker for determining heavy alcohol consumption?
GGTP.
What is the best test for determining alcoholic hepatitis?
SGOT/SGPT ratio is more than 1.
What is the third largest disease burden in the world?
Alcohol, after CAD and DM.
What is the daily alcohol consumption that leads to fatty liver in males?
40-80 grams per day.
What is the daily alcohol consumption that leads to alcoholic hepatitis in males?
160 grams per day for over 10-20 years.
What is the daily alcohol consumption that leads to fatty liver in females?
20 grams per day.
Why do females have a higher chance of developing alcoholic liver disease?
Due to lower BMI, leading to higher alcohol distribution per unit body weight and the influence of estrogen.
What are the chances that a patient with alcoholic hepatitis deteriorates into alcoholic cirrhosis?
50%.
What is the mortality rate over the next 4 years once alcoholic cirrhosis occurs?
60%.
What can binge drinking cause?
Sudden cardiac death due to atrial fibrillation.
What are some risk factors for alcoholic cirrhosis?
HCV, genetics, NAFLD, obesity.
Is fatty liver caused by alcohol reversible?
Yes, it is reversible.
What does fatty liver deteriorate into?
Alcoholic hepatitis.
What are the pathological features of fatty liver?
Ballooning of hepatocytes, macro vesicular fat deposition, neutrophilic infiltrate, spotty necrosis, and active stellate cells.
What are Mallory Denk bodies?
They are not seen by low magnification.
What are the causes of Mallory Denk bodies?
Indian childhood cirrhosis, Wilson Disease, Primary Biliary cirrhosis, Alcoholic Hepatitis, Non-Alcoholic Steatohepatitis (NASH).
What are the clinical features of Mallory Denk bodies?
Asymptomatic, right upper quadrant discomfort, nausea, vomiting, jaundice (absent initially), tender hepatomegaly, history of heavy alcohol intake.
What late signs may be seen in patients with Mallory Denk bodies?
Palmar erythema, spider naevi, Dupuytren contracture, temporal muscle wasting, parotid gland enlargement.
What complications arise from decompensated cirrhosis?
Portal hypertension causing splenomegaly, variceal bleed, and caput medusae.
What is the first step in the workup for Mallory Denk bodies?
Liver function test.
What is the significance of the SGOT/SGPT ratio in alcoholic hepatitis?
The ratio is more than 1, with ALT or SGPT being the most specific LFT.
What is the expected AST or SGOT elevation in alcoholic hepatitis?
AST or SGOT is 2-7 times elevated.
What imaging study is used to check liver span?
Ultrasound (USG).
