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All them viruses Flashcards

1
Q

Picornaviruses

A

Positive Strand Viruses
Naked, 12 pentamer virion
-Rhinovirus, Hepatitis A, & Enteroviruses (Polio & Coxsackievirus)

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2
Q

Flaviviruses

A

Positive Strand Viruses
Enveloped, Icosahedral, non-segmented
-Flavivirus, Hepatitis C

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3
Q

Togaviridae Viruses

A

Positive Strand Viruses
Enveloped, icosahedral, non-segmented, produce full-length & sub-genomic length RNA
-Rubella, Alpha Viruses (EEEV, WEEV, Chikungunya)

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4
Q

Corona Viruses

A

Positive Strand Viruses
Enveloped, Resp/GI spread, non-segmented, helical, #2 cause of URI after Rhinoviruses.
-SARS, MERS

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5
Q

Calcivirus

A

Positive Strand Viruses
Naked, icosahedral, non-segmented, VERY stable.
-Norovirus, Hepatitis E

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6
Q

Rhinovirus

A

(+) Strand, Picornavirus
#1 cause of URT, oronasal entry, sensitive to acid (GI)
ICAM-1 & LDLr receptors (alcohol decreases ICAM expression)
Weak immune response & >140 strains.

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7
Q

Hepatitis A

A 
(+) Strand, Picornavirus
Highly stable. Fecal:oral, food borne.
Acute, not chronic. No Tx, good vaccine.
Worse in adults -> icteric.
Disease: hepatitis caused by CD8+ t-cells attacking hepatocytes. CTL.
Elevated ALT, IgM for acute disease.
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8
Q

Polio

A

(+) Strand, Picornavirus - Enterovirus
Attack motor end-plate. Flaccid paralysis - poliomyelitis.
No tx, good vaccine. Trivalent

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9
Q

Coxsackie

A

(+) Strand, Picornavirus - Enterovirus
Coxsackie A - Hand, foot, mouth disease
Coxcackie B - Bornholm’s Disease (myalgia)

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10
Q

Flavivirus Genus

A

(+) Strand, Flavivirus Group
Arborvirus
Encephalitis: WNV (#1 virus), St. Louis Encephlitis
Hemorrhagic Fever: Yellow Fever - aedes aegypti, Dengue - DHF/DSS occurs in those with previous exposure, lethal.

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11
Q

Hepatitis C

A

(+) Strand, Flavivirus - Hepacvirus
Chronic, IV transmission.
Tx: 95% effective.
Hepatocyte destruction mediated CD8+ Tcells

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12
Q

Alpha Togaviridae Viruses

A

(+) Strand, Togaviridae Viruses
Eastern Equine Encephalitis Virus, Western Equine Encephalitis Virus, Chikungunya
Arborvirus via mesquito. Mild fever to encephalitis

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13
Q

Rubella

A

(+) Strand, Togaviridae Viruses
3rd exanthem. Intrauterine, respiratory spread. Congenital defects.
Tx: no antiviral, but MMR

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14
Q

SARS / MERS

A

(+) Strand, Corona Virus
SARS: horseshoe bats. High mortality. Fever, cough, SOB, headache, viral pneumonia. Destroys alveoli, syncytia.
MERS: bats. Similar Sx.

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15
Q

Norovirus

A 
"Norwalk & Norwalk-like"
(+) Strand, Caliciviruses
Naked, icosahedral, non-segmented, VERY stable.
F:O, foodborne, P2P.
#1 cause of nonbacterial diarrhea.
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16
Q

Hepatitis E

A

(+) Strand, Caliciviruses

In developing countries, acute hepatitis. Not chronic.

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17
Q

Orthomyxoviruses

A

(-) Strand
Segmented genome (8), helical capsid, enveloped
-Influenza A-C

18
Q

Paramyxoviruses

A

(-) Strand
Non-segmented, helical capsid, enveloped.
-Mumps, measles, Parainfluenza, Respiratory Syncytial Virus (RSV), Metapneumovirus

19
Q

Influenza A-C

A

(-) Strand, Orthomyxovirus

20
Q

Mumps

A

(-) Strand, Paramyxovirus

Forms good immunity. Swelling in cheeks and under jaw. Orchitis. Paratoditis. MMR.

21
Q

Measles

A

(-) Strand, Paramyxovirus
Rubeola - 1st exanthem.
Koplik spots. MMR.

22
Q

Parainfluenza Virus 1-4

A

(-) Strand, Paramyxovirus
Mild URI for 4.
Serious URI 1-3. Short lived immunity
Leading cause of Croup cough.

23
Q

Respiratory Syncytial Virus

A

(-) Strand, Paramyxovirus

Bronchiolitis in Lower Respiratory Tract. Kills infected epithelial cells.

24
Q

Metapneumovirus

A

(-) Strand, Paramyxovirus

25
Rabies
``` (-) Strand, Rhabdoviridae Negri bodies, inclusion bodies. Bite - Muscle replication - nerves - DRG replication - brain. 99% fatal if not treated. Incubation 20d-1yr ```
26
Rhabdoviridae
(-) Strand Enveloped, bullet shaped, helical -Rabies, Vesicular Stomatitis Virus
27
Reoviridae Viruses
(-) Strand | Naked, icosahedral, segmented, dsRNA
28
Bunyaviruses
(-) Strand Zoonoses. Enveloped, segmented (L,M,S), helical capsule -Hanta Virus
29
Sin Nombre, Sin Nombre-like, La Crosse
(-) Strand, Bunyaviru - Hanta virus Encephalitis. Mice vector. Dead end host. La Crosse - arborvirus
30
Rotavirus, Reovirus
``` (-) Strand, Reoviridae Virus #1 cause gastroentiritis in children. Damages and replicates in GI epithelium ```
31
HSV-1
DNA Virus - Herpes. Herpes Simplex Virus 1 Multinucleated giant cells & inclusion bodies Tx: acyclovir, foscarnet. Nucleoside analogs Trigeminal ganglion latency
32
HSV-2
DNA Virus - Herpes. Herpes Simplex Virus 2 Less prevalent than HSV-1 Treat with nucleoside analog. Resistant to acyclovir in immunocompromised Pt - use Foscarnet. Spinal ganglion latency
33
Varicella Zoster Virus (VCV)
DNA Virus - Herpes Chickenpox & Zoster (shingles) Replicates in Macrophages & pneumocytes
34
Ebstein Barr Virus (EBV)
DNA Virus - Herpes. Infects oropharynx, moves to Bcells where it replicates & also is latent (swollen LN, spleen). Reactivation in oropharynx Primary: fever, pharyngitis, lymphadenopathy, splenomegaly, atypical lymphocytes (tcells), monospot positive Reactivation: usually Asx, shedding occurs No Tx, Vaccine
35
Cytomegalovirus
DNA Virus - Herpes STI, mucosal. Primary Sx: like mono, negative heterophile, more visceral adenopathy #1 infection cause of congenital birth difects Immune impairment: retinitis, GI ulcers, pneumonia, encephalitis Tx: Ganciclovir
36
Human Herpes Virus 6 (HHV-6)
DNA Virus - Herpes Latency in Tcells, monocytes, macrophages Roseola (6th exanthem), fever Tx usually not necessary
37
Human Herpes Virus 7 (HHV-7)
DNA Virus - Herpes | Similar to HHV-6, can cause roseola
38
Human Herpes Virus 8 (HHV-8)
DNA Virus - Herpes STI associated with AIDS. Latency in Bcells; infects Bcells, endothelium, nn., monocytes. Shed in saliva, semen. Kaposi's Sarcoma! Immune suppression: Castleman's, Bcell lymphoma, primary effusion lymphoma
39
BK Virus
DNA Virus - Polyoma Virus Infections & latency in kidney, CNS, bone marrow Systemic, usually Asx Causes Urinary Tract Infections
40
JC Virus
DNA Virus - Polyoma Virus Infections & latency in kidney, CNS, bone marrow Systemic, usually Asx Causes PML: progressive multifocal leuckoencephalopathy White matter only.
41
Small Pox
DNA Virus - Pox virus | Pearly, painless, umbilicated lesions.
42
Human Papilloma Virus (HPV)
DNA Virus | Koilocytosis CPE

MOHD IV (5 decks)

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