Flashcards in Allergic dermatoses Deck (34):
Atopic Dermatitis (AD)
Inflammatory and PRURITIC skin disease with strong genetic predispositions.
Animals with AD tend to develop ___ - mediated response against _____.
Develop IgE mediated response against environmental allergens.
pathophys of the pruritis of AD
absorption of allergen (skin) -> langerhans cells present to TH cells -> dorsal root ganglion - > brain -> meanwhile immune cells are communicating with each other and are increasing inflammation.
patients with AD have mutation in the ____ gene
dogs with AD have decreased barrier function d/t decreased ___ in between epithelial cells -
important cytokine that can be targeted with treatment of AD
clinical features of AD
ventrum, face, feet, perianal area
signs of inflammation (what are they)
Treatment options for AD
- GCs (ORAL! short acting; don't use long acting injeectable)
* Temaril P = antihistamine + pred
- omega 3 FAs
- topical, bathing
- allergen-specific desensitization therapy
- cyclosporine (Atopica)
- Oclacitinib (Apoquel)
What is a side effect in dogs secondary to too much steroids? (aka bad news)
Calcinosis cutis - disrupts skin, plus you're suppressing immune system, increased risk of 2' bacterial infections
Why are free fatty acids helpful for AD?
helps to restore the integrity of the skin. Incorporate into your long-tern treatment.
Most 'allergy shampoos' contain ____
Potent topical steroids should be managed like ____.
systemic steroids; because they cant disrupt the skin! make sure to follow label directions.
The goal of allergy immunization is to ___
desensitize the patient to allergens
___ is the gold standard for AD testing
Which drugs can interfere with intradermal allergen test results?
Allergy immunotherapy targets ___ and __ cells (theoretically
T helper & mast cells
Allergy drops are administered to the animal ___
under the tongue, every day
Animals that failed to respond to allergy ____ tend to respond to allergy ___
cyclosporine (atopica) reduces pruritis by ___
blocking calcineurin -> block transcription of inflammatory mediators
cyclosporine is metabolixed by ____
Do not give apoquel to patients under ____ age
Apoquel is a ___ inhibitor
JAK 1 & 2. Provides anti-pruritic and immune-modulatory drug
Mechanism of action of cytopoint is ___
Anti-IL 31 monoclonal antibody. IL 31 is a major player in pruritis
Food allergies (cutaneous adverse food reactions) are mediated by what immunologic reactions?
IgE mediated (type I and type III)
Mechanisms of defense of the gut
paneth cells (secrete antimicrobial peptides)
epithelial tight junctions
dermatologic sites affected by food allergies
eyes, mouth, distal limbs, ventrum, bum.
key distinguishing factor between AD (environmental allergies) and food allergies
seasonal vs. non seasonal! (usually)
food allergy dogs commonly present with
otitis recurrent pyodermas, GI.
uncommonly, can see vasculitis, urticaria, erythema multiforme (target skin lesions)
blood allergy test [are/are not] reliable for food allergy?
diagnosis of food allergies
elimination diet trial, provocative exposure
Treatment of food allergy
change the diet
avoid treats, flavored drugs/supplemented
treat the pruritis (initially) GCs, apoquel, cytopoint. have to take off after a while to see if your diet is working
Mechanism by which hydrolyzed diets work
the peptide bonds of large proteins so that they become <10KDaltons -> don't activate IgE on mast cells
grain- free, organic foods [are/are not] good for treating food allergies
NOT. often have cross-contamination in manufacturing process