Allergic dermatoses Flashcards Preview

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Flashcards in Allergic dermatoses Deck (34):
1

Atopic Dermatitis (AD)
Definition

Inflammatory and PRURITIC skin disease with strong genetic predispositions.

2

Animals with AD tend to develop ___ - mediated response against _____.

Develop IgE mediated response against environmental allergens.

3

pathophys of the pruritis of AD

absorption of allergen (skin) -> langerhans cells present to TH cells -> dorsal root ganglion - > brain -> meanwhile immune cells are communicating with each other and are increasing inflammation.

4

patients with AD have mutation in the ____ gene

filaggrin

5

Barrier function
dogs with AD have decreased barrier function d/t decreased ___ in between epithelial cells -

ceramides

6

important cytokine that can be targeted with treatment of AD

IL31 ***

7

clinical features of AD

1-3 yo
seasonal pruritis
ventrum, face, feet, perianal area
signs of inflammation (what are they)

8

Treatment options for AD

SYMPTOMATIC
- antihistamines
- GCs (ORAL! short acting; don't use long acting injeectable)
* Temaril P = antihistamine + pred
- omega 3 FAs
- topical, bathing
SPECIFIC
- allergen-specific desensitization therapy
- cyclosporine (Atopica)
- Oclacitinib (Apoquel)

9

What is a side effect in dogs secondary to too much steroids? (aka bad news)

Calcinosis cutis - disrupts skin, plus you're suppressing immune system, increased risk of 2' bacterial infections

10

Why are free fatty acids helpful for AD?

helps to restore the integrity of the skin. Incorporate into your long-tern treatment.

11

Most 'allergy shampoos' contain ____

hydrocortisone

12

Potent topical steroids should be managed like ____.

systemic steroids; because they cant disrupt the skin! make sure to follow label directions.

13

The goal of allergy immunization is to ___

desensitize the patient to allergens

14

___ is the gold standard for AD testing

intradermal testing

15

Which drugs can interfere with intradermal allergen test results?

antihistamines
corticosteroids

16

Allergy immunotherapy targets ___ and __ cells (theoretically

T helper & mast cells

17

Allergy drops are administered to the animal ___

under the tongue, every day

18

Animals that failed to respond to allergy ____ tend to respond to allergy ___

shots; drops

19

cyclosporine (atopica) reduces pruritis by ___

blocking calcineurin -> block transcription of inflammatory mediators

20

cyclosporine is metabolixed by ____

CYP450

21

Do not give apoquel to patients under ____ age

12 mos

22

Apoquel is a ___ inhibitor

JAK 1 & 2. Provides anti-pruritic and immune-modulatory drug

23

Mechanism of action of cytopoint is ___

Anti-IL 31 monoclonal antibody. IL 31 is a major player in pruritis

24

Food allergies (cutaneous adverse food reactions) are mediated by what immunologic reactions?

IgE mediated (type I and type III)
Type IV

25

Mechanisms of defense of the gut

IgA
paneth cells (secrete antimicrobial peptides)
epithelial tight junctions
m cells
lymph nodes

26

dermatologic sites affected by food allergies

eyes, mouth, distal limbs, ventrum, bum.

27

key distinguishing factor between AD (environmental allergies) and food allergies

seasonal vs. non seasonal! (usually)

28

food allergy dogs commonly present with

otitis recurrent pyodermas, GI.
uncommonly, can see vasculitis, urticaria, erythema multiforme (target skin lesions)

29

blood allergy test [are/are not] reliable for food allergy?

NOT

30

diagnosis of food allergies

elimination diet trial, provocative exposure

31

Treatment of food allergy

change the diet
avoid treats, flavored drugs/supplemented
treat the pruritis (initially) GCs, apoquel, cytopoint. have to take off after a while to see if your diet is working

32

Mechanism by which hydrolyzed diets work

the peptide bonds of large proteins so that they become <10KDaltons -> don't activate IgE on mast cells

33

grain- free, organic foods [are/are not] good for treating food allergies

NOT. often have cross-contamination in manufacturing process

34

treatment for food allergies

pyoderma
- abx
otitis
- otomax
- miconazole
- osurnia
pruritis
- cytopoint
- temaril p
- aproquel
food trial
- Dr. mel has success with rabbit
sweet potato
apple