Alpha Adrenergic Antagonists

Question 1

Phentolamine has a duration of action of ___________ (15-50hrs/1-2hrs)

Answer 1

1-2hrs

Question 2

Phentolamine is used for the short term management of _________________

Answer 2

Pheochromocytoma

Question 3

Phentolamine is a ___________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)

Answer 3

nonselective competetive alpha blocker

Question 4

Phentolamine produces ____________ (postural hypotension/bronchoconstriction) and epinephrine reversal.

Answer 4

postural hypotension

Question 5

___________ (phentolamine/prazosin) is used to treat dermal necrosis following extravasation of epinephrine.

Answer 5

Phentolamine

Question 6

Prazosin is prototype of _______________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)

Answer 6

selective competetive alpha 1 blocker

Question 7

___________ (prazosin/phenylephrine) reduces peripheral resistance and blood pressure.

Answer 7

Prazosin

Question 8

Prazosin has a _______ (short/long) duration of action

Answer 8

long (10hrs)

Question 9

Prazosin has a ________ (slow/rapid) onset

Answer 9

slow (2-4hrs)

Question 10

ROA of Prazosin is _______ (oral/IV)

Answer 10

oral

Question 11

Prazosin is sold under the brand name _________

Answer 11

Minipress

Question 12

Phentolamine is sold under the brand name __________

Answer 12

Regitine

Question 13

ROA of phentolamine is ________ (oral/IV)

Answer 13

IV

Question 14

Tamsulosin and Silodosin have greater efficacy for treatment of ____________

Answer 14

Benign Prostatic Hyperplasia

Question 15

Tamsulosin has selective action at ____________ (alpha 1A/alpha 1B) receptors on the bladder and prostate

Answer 15

alpha 1A receptors

Question 16

Phenoxybenzamine has a ________(short/long) duration of action because it binds covalently

Answer 16

long (15-50hr) about 24hrs

Question 17

Inactive products of _________ (Doxazosin/Alfuzosin) are excreted in feces.

Answer 17

Doxazosin

Question 18

Out of all the drugs, ___________ is the longest acting. (prazosin/tamsulosin/alfuzosin/doxazosin)

Answer 18

Doxazosin

Question 19

Phenoxybenzamine is a ____________ (noncompetetive/competetive) irreversible antagonist with some selectivity for ________ (alpha 1/alpha 2) receptors although it works at both.

Answer 19

noncompetetive

alpha 1

Question 20

Phenoxybenzamine is sold under the brand name __________

Answer 20

Dibenzyline

Question 21

_____________ (Prazosin/Phenoxybenzamine) is sometimes useful for the treatment for frostbite and Raynaud disease.

Answer 21

Phenoxybenzamine

Question 22

Phenoxybenzamine is no longer used to treat hypertension because it blocks ____________ (presynaptic inhibitory alpha 2/alpha 1) receptors in the heart leading to an increased cardiac output.

Answer 22

presynaptic inhibitory alpha 2 receptors

Question 23

Reflex tachycardia is one of the adverse effect of ____________ and ____________ (phenoxybenzamine/prazosin/tamsulosin/phentolamine)

Answer 23

phenoxybenzamine and phentolamine

Question 24

___________ (alfuzosin/phentolamine) is used for the treatment of BPH

Answer 24

Alfuzosin

Question 25

______________ is contraindicated in coronary artery disease because it triggers arrhythmias and anginal pain

Answer 25

Phenoxybenzamine

Question 26

All alpha adrenergic blockers reverse the alpha agonist actions of epinephrine. This is known as ___________

Answer 26

Epinephrine reversal

Question 27

Alpha 1B receptors are found on ___________ (blood vessels/prostate/bladder

Answer 27

blood vessels

Question 28

Blockade of alpha 1A receptors __________ (increases/decrease) the tone of smooth muscle of the bladder and prostate.

Answer 28

decreases

Question 29

_____________ (Phentolamine/Tamsulosin) improves urine flow in patients of BPH

Answer 29

Tamsulosin

Question 30

_____________ (Prazosin/Phenoxybenzamine is useful in the chronic managment of inoperable tumors of adrenal glands

Answer 30

Phenoxybenzamine

Question 31

FIrst dose of _________ may produce an exaggerated orthostatic hypotensive response that can result in syncope.

Answer 31

alpha 1 blockers

Question 32

___________ are not used as monotherapy for the treatment of hypertension because of low outcomes.

Answer 32

alpha 1 blockers

Question 33

___________ (Phentolamine/Phenoxybenzamine) may inhibit ejaculation

Answer 33

Phenoxybenzamine

Question 34

_____________ should be used with caution in patients wiith cardivascular or cerebrovascular disease

Answer 34

Phenoxybenzamine

Question 35

What are some adverse effects of phenoxybenzamine?

Answer 35

``` Postural hypotension Nausea Vomiting Nasal stuffiness Reflex tachycardia Inhibit ejaculation ```

Question 36

______________ have been used as an alternative to surgery in patients with BPH

Answer 36

Alpha 1 blockers

Question 37

What are some adverse effects of alpha 1 blockers?

Answer 37

``` Dizziness Lack of energy Nasal congestion Headache Drowsiness Orthostatic hypotension Inhibition of ejaculation Retrograde ejaculation Floppy iris syndrome (during intraoperative eye surgery) ```

Question 38

An additive _________ (hypertensive/antihypertnesive) effect occurs when alpha 1 blockers are given with vasodilators such as nitrates or PDE-5 inhibitors (sildenafil)

Answer 38

Antihypertensive

Question 39

__________ is an example of selective competetive alpha 2 blocker.

Answer 39

Yohimbine

Question 40

Yohimbine works at the level of the CNS to _________ (increase/decrease) the sympathetic outflow to the periphery.

Answer 40

Increase

Question 41

_____________ is containdicated in cardiovascular disease, psychiatric conditions and renal dysfunction

Answer 41

Yohimbine

Question 42

___________ was used as a sexual stimulant and in the treatment of erectile dysfunction.

Answer 42

Yohimbine

Question 43

Alfuzosin is sold under the brand name of __________

Answer 43

Uroxatral

Question 44

Doxazosin is sold under the brand name of _________

Answer 44

Cardura

Question 45

Tamsulosin is sold under the brand name of ________

Answer 45

Flomax

Question 46

Terazosin is sold under the brand name of __________

Answer 46

Hytrin

Question 47

Yohimbine is sold under the brand name of ________

Answer 47

Yocon