Alpha and Beta Antagonist ppt

Question 1

The autonomic nerouns are divided into what 2 parts

Answer 1

preganglionic and post ganglionic

Question 2

which sneurons leaves the spinal cord fromthe cranial, thoracic and lumbar or sacral region to form a synaptic connection

Answer 2

preganglionic

Question 3

which nerons section sends their axons directly to the effector organ?

Answer 3

post ganglionic

Question 4

Most Postganglionic autonomic nerves are what?

Answer 4

Nonmylinated and have slow conductino

Question 5

Most preganglionic neurons are what

Answer 5

mylinated an dhave fast conduction

Question 6

there are ___ segmentally arranged ganglia that cansit of 2 chains bilat down spinal cord

Answer 6

22

Question 7

which ganlionic nerves are short and which are long?

Answer 7

pre short

post long

Question 8

what NT mediates synaptic transmission B/T preganglionic and post ganglionic nerve fiber in the Sympathetic pathway

Answer 8

ACh

Question 9

what is the NT if the postganglionic sypathetic nerve pathway (at the end organ junction)

Answer 9

NE

Question 10

sites that use ACh as their NT are termed

Answer 10

cholinergic

Question 11

sites that use NE as the NT are termed

Answer 11

adrenergic

Question 12

*****************************************

the adrenal Medulla unlike the postganglionic sympathetic nerve terminal, releases what as it’s primary catecholamine

Answer 12

Epinephrine

Question 13

a good pic to refer to notice the short preganlionic neurons and the long postganglionic neurons.

also notice the PNS vs the SNS and thier NT

Answer 13

Question 14

Autonomic regulation of periphreral involuntary organs

most organs receive duel innervation consiting of _____ and _____ components

if blockade of one system is acheived it leads to ________ of response by the other

Answer 14

SNS and PNS

exaggeration

Question 15

******************************************

in both the SNS and PNS ganglia the NT released by the preganglionic neurons is what?

Answer 15

ACh

Question 16

another pic to look at understand and master

Answer 16

Question 17

**********************

the postganglionic sympathetic NT is what

Answer 17

NE

Question 18

******************************

the post ganglionic parasympathetic NT is what

Answer 18

ACh

Question 19

how is ACh broken down

Answer 19

via acetylcholinesterase into acetic acid and choline

Question 20

How is NE broken down

Answer 20

MAO

COMT

Question 21

what are the 2 types of ADRENERGIC receptors

Answer 21

alpha

Beta

Question 22

what are the 2 types of CHOLINERGIC receptors

Answer 22

Nicotinic and Muscarinic

Question 23

********************

Alpha 1

Answer 23

Vasoconstricin

Increased inotropy

Question 24

***********

alpha 2

Answer 24

decreased SNS flow

NE release inhibited

Vasodilation

Decreased Chronotropy

Question 25

\*\*\*\*\*\*\*\*\*\*\*\*\* Beta 1

Answer 25

Increased Chronotropy Increased Inotropy Increased Dromotropy

Question 26

\*\*\*\*\*\*\*\*\*\*\* Beta 2

Answer 26

Increased inotropy Increased Chronotropy periphreal vasodilation bronchodilation works on pipes arteries and bronchi

Question 27

what do Alpha antagonist do

Answer 27

interfere with the ability of catecholamines to provoke an alpha response prevents effects of catecholamines on heart and vasculature Inhbitory actin of epinephrine on insulin secretion

Question 28

Main SE of alpha blockers

Answer 28

orthostatic hypotension reflex tachycardia impotence

Question 29

\*\*\*\*\*\*\*\*\*\*\*\*\*\* MOA r/t binding of the Aplha blockers phentolamine, prazosin, and yohimbine

Answer 29

competative antagonist (reversiable

Question 30

\*\*\*\*\*\*\*\*\*\*\* MOA r/t binding with the alpha blocker Phenoxybenzamine

Answer 30

Covalently bonds

Question 31

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* 4 ex of alpha antagonist

Answer 31

phentolamine prazosin yohimbine Phenoxybenzamine

Question 32

\*\*\*\*\*\*\*\*\*\*\*\* which Alpha blocker is selective for alpha 1 receptors

Answer 32

Prazosin

Question 33

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* which Alpha blocker is selective for alpha 2 receptors

Answer 33

yohimbine

Question 34

\*\*\*\*\*\*\*\*\*\*\*\*\*\* which 2 alpha blockers are nonselective antagonist

Answer 34

phentolamine and Phenoxybenzamine

Question 35

phentolamin causes peripheral vasodilation and decreased B/p how fast? last how long

Answer 35

with in 2 min 10-15 min

Question 36

what is the principle use for phentolamine

Answer 36

tx of acute htn emergencies such as introp manipulation of pheochromocytoma or autonomic hyperreflexia

Question 37

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* onset and duration of Phenoxybenamine

Answer 37

60 min 1/2 time 24 hours 9cumulative) due to covalent bond

Question 38

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*clinical uses of phenoxybenzamine

Answer 38

pre-op control of bp in phenochromoctoma excessive vasoconstriction in hemorrhagic shock

Question 39

what is yohimbine used for

Answer 39

for rare pt with idiopathic orthostatic hypotensino

Question 40

which Alpha blocker is less likely to cause reflex tachycardia

Answer 40

prazosin

Question 41

Beta antogonist are derivative of what beta-agonist drug

Answer 41

isoproterenol

Question 42

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* which beta-adrenergic receptor antagonist is the only one cleared by plasma hydrolysis

Answer 42

Esmolol

Question 43

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* what are the onle 2 beta-adrenergic receptor antagonist that have active metabolites

Answer 43

propranolol acebutolol

Question 44

what types of pts are selective B1 blockers good for and why

Answer 44

for asthma and COPDers b/c it will save B2 effects

Question 45

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* which BB has rapid onset, is a short acting B 1 selective antagonist, and onlt administered IV

Answer 45

esmolol

Question 46

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* the full effect of esmolol is evident within how long? and ceases after how long

Answer 46

5 min 10-30

Question 47

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* contraindications for BB

Answer 47

AV Blockheart failure

Question 48

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* what is teh drug of choice for massive BB overdose and why?

Answer 48

Glucagon 1-10mg IV bc it stimulates adecylate cyclase and increases intracellular cAMP

Question 49

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* Beta 2 receptor stimulation tends to facilitate the movement of what intracellularly

Answer 49

K+

Question 50

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* what drug is a Selective A-1 and non-selective B-1 and B-2 blocker

Answer 50

labetalol

Question 51

\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*with labetalol the beta to alpha blocking potentcy is \_\_:\_\_ for oal and \_\_:\_\_ for IV

Answer 51

3: 1 7: 1

Question 52

DONE

Answer 52

Bitches

Question 53

I said done

Answer 53

Bitches