Alpha and Beta Receptors Flashcards Preview

MABS Neuroscience > Alpha and Beta Receptors > Flashcards

Flashcards in Alpha and Beta Receptors Deck (18)
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1
Q

where can you find alpha 1 receptors?

A

vascular smooth muscle, on GI and bladder sphincters, and radial muscle of the eye causing excitation (contraction)

2
Q

this cholinergic receptor is g-coupled

A

alpha 1 receptors

3
Q

this cholinergic receptor increases IP3

A

alpha 1 receptors

4
Q

where can you find alpha 2 receptors?

A

presynaptic nerve terminals, platelets, fat cells, walls of GI tract

5
Q

this adrenergic receptor causes inhibition?

A

alpha 2 receptor

6
Q

Cholinergic and Adrenergic receptors are G-protein coupled? Are nicotinic receptors?

A

true; no

7
Q

what is the effect of activating the alpha 2 receptors?

A

inhibition of adenylate cyclase and decrease in cAMP causing inhibition (dilatation)

8
Q

where can you find the beta 1 receptors?

A

SA node, AV node, ventricular muscle of heart

9
Q

what is the effect of Beta 1 receptors?

A

stimulation of adenylate cyclase and increase in cAMP causing excitation (increaes heart rate, contactility, increased conduction velocity)

10
Q

where can you find Beta 2 receptors?

A

vascular smooth muscle of skeletal muscle, bronchioles, walls of GI tract and bladder

11
Q

what is the effect of Beta 2 receptors?

A

stimulation of adenylate cyclase and increase in cAMP, increase epinephrine and this produces relaxation (dilation of vascular smooth muscle and bronchioles, relaxation of bladder wall)

12
Q

Which of the following are Gq coupled and/or Gi coupled for cholinergic receptors? M1, M2, M3; are these G-protein coupled receptors

A

M1 and M3 are Gq coupled

M2 is Gi coupled

13
Q

which of the following are Gq coupled and/or Gi coupled for adrenergic receptors? alpha 1, alpha 2, Beta 1, Beta 2, Dopaminergic 1

A

alpha 1 is Gq coupled

alpha 2 is Gi coupled

Beta 1, Beta 2, Dopaminergic is Gs coupled

14
Q

since M1 and M3 are are Gq coupled, what is the effect?

what type of receptors are these?

A

increase phospholipase C -> increase IP3, DAG, and calcium; cholinergic

15
Q

since M2 is Gi coupled, what is the effect? what type of receptors are these?

A

decrease adenylyl cyclase -> decrease cAMP; cholinergic

16
Q

since alpha 1 is Gq coupled, what is the effect?what type of receptor is this?

A

increase phospholipase C -> increase IP3, DAG, Calcium; adrenergic

17
Q

since alpha 2 is Gi coupled, what is the effect?what type of receptor is this?

A

decrease adenylyl cyclase -> decrease cAMP; adrenergic

18
Q

since Beta 1, Beta 2, and dopaminergic 1 is Gs coupled what is the effect? what type of receptor is this?

A

increase adenylyl cyclase -> increase cAMP; adrenergic

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