Alpha-Glucosidase Inhibitors

Question 1

Common drugs

Answer 1

Acarbose

Question 2

MOA

Answer 2

Inhibits digestive enzymes, delaying glucose absorption

Question 3

Contraindications

Answer 3

Cirrhosis

Caution in renal impairment

Question 4

Serious adverse reactions

Answer 4

Slight rise in hepatic aminotransferases (5% vs 2% in placebo group) - reduces when d/c’d
Hypoglycemia (if used w/insulin or SU)

Question 5

Common adverse reactions

Answer 5

Flatulence (20-30%) - d/t undigested carbohydrates

Diarrhea (3%)