Alzheimer's

Question 1

What is Alzheimers

Answer 1

The loss of cognitive functioning and behavioural abilities

Question 2

Mild stage (Alzheimers)

Answer 2

Short-term memory
Hard to learn & retain information

Question 3

Intermediate stage (Alzheimers)

Answer 3

Older/distant memory
Difficult to recover events/people from earlier life

Question 4

Severe stage (Alzheimers)

Answer 4

Difficulty in speaking thoughts, carrying out simple acts, recognizing people/objects

Question 5

Amyloid palques

Answer 5

beta-amyloid 42 clump up, blocking communications and leading to cell death

Question 6

Beta-amyloid 42

Answer 6

broken-down amyloid precursor protiens break up into pieces, including beta-amyloid 42

Question 7

Neurofibrillary Tangles

Answer 7

abnormal accumulations of tau

Question 8

Tau

Answer 8

Normally - support microtubules
Alzheimer’s - breaks away from microtubules, sticks together, blocks nutrients from getting to parts of the cell

Question 9

TREM2

Answer 9

Gene that activates microglia to remove beta-amyloid plates. If this gene mutates microglia can’t do their job

Question 10

Chronic inflammation

Answer 10

TREM2 mutates, and plaque builds up. Both microglia and astrocytes are unable to clean up and release more chemicals, further inflaming the brain