Alzheimer's Disease Flashcards
(14 cards)
What are Neurofibrillary Tangles?
threadlike tangles of proteins in the neuron cytoplasm
What are amyloid Plaques?
clumps of scar tissues composed of degenerating protein called amyloid
what is the main hypothesis of the primary symptom?
Amyloid Plaques
why is the amyloid plaques hypothesis not trusted?
researchers cant find a way pf reducing amyloid deposits
What were the first efforts of the amyloid plaque hypothesis?
From declines in achtcoline levels where cholinergic agonists are still prescribed but ineffective.
What is the kindling phenomenon?
electric stimuli applied a day causes epilepsy like seizures eventually rather than automatically
what underlying process of the kindling phenomenon is permanent?
Neuroplasticity
What deficits are found within memory?
short-term memory and implicit memory
Where is neuron loss common in general?
areas of mediating complex executive functions
Why is neuron loss prominent?
Results from degeneration of basal forebrain
Which medial temporal lobe structures experience neuron loss in AD?
hippocampus, amygdala and entorhinal cortex
Which parts of the cortex experience neuron loss in AD?
Inferior temporal, posterior parietal and prefrontal.
What does Transgenic mean?
refers to animals into which genes of another species have been introduced.
What does epileptogenesis mean?
the development or genesis of epilepsy
