Alzheimer's Disease

Question 1

What is early onset AD?

Answer 1

Onset of dementia before the age of 65

Question 2

What is late onset AD?

Answer 2

Onset of dementia after the age of 65

Question 3

Genetic factors in Late onset AD?

Answer 3

The gene encoding for the ApoE 4 allele increases risk

Question 4

Genetic Factors in early onset AD

Answer 4

Possession of :
Amyloid precursor protein
Presenilin- 1
Presenilin-2

Question 5

Why are Adults with down symdrome more at risk of AD?

Answer 5

APP in on chromosome 21 which is triplicated

Overexpressed

Question 6

Gross pathology of the brain

Answer 6

Generalised atrophy of the rain
Widened Sulci
Enlarged ventricles
Most marked in the frontal and temporal lobes

Question 7

Microscopic findings in AD

Answer 7

Intracellular neurofibrillary tangles resulting from abnormal phosphorylation of tau protein
Intracellular cytoplasmic vacuoles
Extracellular senile plaques: beta amyloid, aluminium and silica
Amyloid deposition in the walls of the blood vessels