Amboss sulfasalazine

Question 1

sulfasalazine. mechanism

Answer 1

Prodrug converted in vivo to sulfapyridine (a sulfonamide anti-infective) (aka antibacterial)
and
5-aminosalicylic acid (mesalamine; anti-inflammatory agent).

Question 2

Sulfasalazine. indication

Answer 2

ulcerative colitis, crohn disease (colitis component)

Rheumatoid Arthritis in Adults

Question 3

sulfasalazine adverse?

Answer 3

malaise, nausea, SULFONAMIDE TOXICITY, sulfa alergy (hypersensitivity), !!!!REVERSIBLE OLIGOSPERMIA (infertility)
hematologic effect - agranulocytosis, aplastic anemia.

Question 4

orlistat. mechanism?

Answer 4

Reversible inhibition of gastric and pancreatic lipase → ↓ breakdown and absorption of fat

Question 5

orlistat. indications?

Answer 5

Weight loss in patients with obesity

Question 6

orlistat. adverse?

Answer 6

Predominantly gastrointestinal side effects (e.g., pain, diarrhea, flatulence, malabsorption of fat-soluble vitamins)

Question 7

orlistat use concomitantly with ADEK vitamins (once-daily)

Answer 7

.

Question 8

loperamide. mechanism?

Answer 8

agonist at u-opioid receptors; slows gut motility.

Question 9

loperamide. indications?

Answer 9

Antiperistaltic antidiarrhea agent.
indication - diarrhea

also, Reduction of discharge volume from ileostomies

Question 10

loperamide. enzymes?

Answer 10

CYP3A4 or CYP2C8 inhibitors

Question 11

loperamide addiction?

Answer 11

Poor CNS penetration –> low addictive potential

Question 12

loperamide. adverse?

Answer 12

nausea, constipation. Can be severe cardiovascular adverse.