Amiodarone (Cordarone)

Question 1

Amiodarone (Cordarone) class

Answer 1

Class III antiarrhythmic

Question 2

Amiodarone (Cordarone) MOA

Answer 2

• Antiarrhythmic effect by prolonging phase 3
• Sodium channel, beta blocker and calcium channel “like” effects
• Negative chronotropy

Question 3

Amiodarone (Cordarone) indications

Answer 3

• Vfib/ pulseless vtach refractory to defib

- Vtach refractory to cardioversion

Question 4

Amiodarone (Cordarone) contraindications

Answer 4

• Neonates
• Hypersensitivity to iodine (IV dye)
• High degree heart blocks
• Marked sinus bradycardia

Question 5

Amiodarone (Cordarone) kinetics

Answer 5

Onset: 5-15 minutes
Duration: variable

Question 6

Amiodarone (Cordarone) adverse effects

Answer 6

• Hypotension
• Bradycardia
• Cardiogenic shock
• Decompensated heart failure

Question 7

Amiodarone (Cordarone) dose for Vfib/ pulseless Vtach refractory to defibrillation

Answer 7

300mg IV/IO rapid bolus diluted in 20 ml NS

Question 8

Amiodarone (Cordarone) dose if cardiac arrest persist

Answer 8

150mg IV/IO bolus over :30 in 10ml NS