AML

Question 1

What is the most common type of leukemia in adults?
A) Acute lymphoblastic leukemia
B) Chronic myeloid leukemia
C) Acute myeloid leukemia
D) Hairy cell leukemia

Answer 1

C) Acute Myeloid leukemia

Question 2

The WHO classification of AML is based on:
A) Morphology and cytochemistry
B) Cytogenetics and molecular characterization
C) Age of the patient
D) The presence of Auer rods

Answer 2

B

Question 3

Which of the following stains is positive in AML?
A) PAS
B) MPO
C) ANAE
D) FVIII

Answer 3

Answer: B) MPO

Question 4

What is a common presenting sign of AML?
A) Jaundice
B) Pallor
C) Polycythemia
D) Weight gain

Answer 4

Answer: B) Pallor

Question 5

Tumor lysis syndrome in AML is characterized by:
A) Hypouricemia
B) Hypophosphatemia
C) Hyperkalemia
D) Hypercalcemia

Answer 5

Answer: C) Hyperkalemia

Question 6

Which genetic abnormality is associated with a favorable prognosis in AML?
A) t(9;11)
B) t(8;21)
C) Complex karyotype
D) del(7q)

Answer 6

B

Question 7

Acute promyelocytic leukemia (APL) is treated with:
A) Hydroxyurea
B) Vincristine
C) ATRA and arsenic trioxide
D) Methotrexate

Answer 7

C

Question 8

APL is associated with which characteristic cell type?
A) Smudge cells
B) Faggot cells
C) Reed-Sternberg cells
D) Plasma cells

Answer 8

Answer: B) Faggot cells

Question 9

Which mutation is commonly found in AML with monocytic features?
A) RUNX1
B) NPM1
C) BCR-ABL
D) JAK2

Answer 9

Answer: B) NPM1

Question 10

AML with minimal differentiation (M0) is negative for:
A) MPO
B) SBB
C) Both MPO and SBB
D) PAS

Answer 10

Answer: C) Both MPO and SBB

Question 11

Which translocation is found in APL?
A) t(9;22)
B) t(15;17)
C) t(8;14)
D) t(11;14)

Answer 11

Answer: B) t(15;17)

Question 12

Which AML subtype has the worst prognosis?
A) AML with NPM1 mutation
B) AML with biallelic CEBPA mutation
C) AML with RUNX1 mutation
D) AML with t(8;21)

Answer 12

Answer: C) AML with RUNX1 mutation

Question 13

AML with myelodysplasia-related changes primarily affects:
A) Children
B) Young adults
C) Older adults
D) Infants

Answer 13

Answer: C) Older adults

Question 14

Therapy-related AML is associated with prior treatment using:
A) Antidepressants
B) NSAIDs
C) Alkylating agents
D) Beta-blockers

Answer 14

Answer: C) Alkylating agents

Question 15

AML with maturation (M2) has what percentage of blasts?
A) <10%
B) >20%
C) 50-60%
D) 70-80%

Answer 15

Answer: B) >20%

Question 16

AML with monocytic differentiation is known as:
A) M2
B) M3
C) M4
D) M5

Answer 16

Answer: D) M5

Question 17

Pure erythroid leukemia (M6) is characterized by:
A) >50% neutrophils
B) >80% erythroid precursors
C) >30% monoblasts
D) >20% megakaryoblasts

Answer 17

B

Question 18

Which AML subtype is associated with Down syndrome?
A) M0
B) M3
C) M7
D) M4

Answer 18

Answer: C) M7

Question 19

Sudan Black B (SBB) stains which cell component?
A) DNA
B) RNA
C) Lipids
D) Proteins

Answer 19

Answer: C) Lipids

Question 20

Myeloperoxidase (MPO) stain is positive in:
A) Lymphocytes
B) Granulocytes
C) Erythrocytes
D) Megakaryocytes

Answer 20

Answer: B) Granulocytes

Question 21

AML with t(9;11) is associated with:
A) Neutrophilic differentiation
B) Increased monoblasts
C) Increased eosinophils
D) Increased megakaryocytes

Answer 21

Answer: B) Increased monoblasts

Question 22

Which is a diagnostic criterion for AML?
A) <5% blasts in bone marrow
B) >20% blasts in bone marrow
C) >30% eosinophils
D) <10% myeloid precursors

Answer 22

Answer: B) >20% blasts in bone marrow

Question 23

AML with t(8;21) has a better prognosis due to:
A) High white blood cell count
B) Favorable genetic abnormality
C) High number of monocytes
D) Presence of Auer rods

Answer 23

B

Question 24

Therapy-related myeloid neoplasms account for:
A) <1% of AML cases
B) 5-10% of AML cases
C) 10-20% of AML cases
D) >50% of AML cases

Answer 24

Answer: C) 10-20% of AML cases

Question 25

Myeloid sarcoma primarily affects: A) Bone marrow B) Skin and GI tract C) Lymph nodes only D) CNS exclusively

Answer 25

Answer: B) Skin and GI tract

Question 26

Which AML subtype has a higher incidence in children? A) M3 B) M4 C) t(9;11) AML D) M7

Answer 26

Answer: C) t(9;11) AML

Question 27

AML with gingival infiltration is most commonly: A) M1 B) M2 C) M5 D) M7

Answer 27

Answer: C) M5

Question 28

AML with inv(16) has a high relapse rate in the: A) Bone marrow B) Lymph nodes C) CNS D) Spleen

Answer 28

Answer: C) CNS

Question 29

AML without maturation (M1) typically has: A) >90% blasts in the bone marrow B) >10% mature neutrophils C) Predominance of erythroid precursors D) Presence of megakaryocytes

Answer 29

Answer: A) >90% blasts in the bone marrow

Question 30

AML with maturation (M2) is distinguished by: A) Blasts >50% of bone marrow cells B) Presence of at least 10% maturing neutrophils C) Absence of Auer rods D) More than 80% monoblasts

Answer 30

Answer: B) Presence of at least 10% maturing neutrophils

Question 31

Which AML subtype is associated with t(15;17)? A) AML M2 B) AML M3 C) AML M5 D) AML M6

Answer 31

B

Question 32

AML M3 is often complicated by: A) Hypercalcemia B) Hemophagocytic syndrome C) Disseminated intravascular coagulation (DIC) D) CNS infiltration

Answer 32

C

Question 33

Which cytogenetic abnormality is most commonly associated with AML M6? A) t(8;21) B) t(15;17) C) Chromosome 5 and 7 abnormalities D) JAK2 mutation

Answer 33

C

Question 34

Which marker is most specific for AML M7? A) CD14 B) CD33 C) CD41 and CD61 D) CD34

Answer 34

Answer: C) CD41 and CD61

Question 35

Which AML subtype is associated with high factor VIII staining? A) M3 B) M4 C) M6 D) M7

Answer 35

Answer: D) M7