Amphetamine

Question 1

In the experiment that investigated amphetamine sensitization in humans, evidence for
sensitization was provided by demonstrating:
a. the subjective effects of amphetamine decreased with repeated exposure.
b. the objective effects of amphetamine, as measured by eye blink rate, decreased with
repeated exposure.
c. the binding potential of [11C]raclopride in the ventral striatum was increased during the
last dose (i.e., dose 5) compared to the first dose (i.e., dose 1).
d. the binding potential of [11C]raclopride in the ventral striatum was decreased during the
last dose (i.e., dose 5) compared to the first dose (i.e., dose 1).

Answer 1

d)
the binding potential of [11 C]raclopride in the ventral striatum was decreased during the last dose compared to the first dose

Question 2

Withdrawal from amphetamine is characterized by
a. depression.
b. increased sleep.
c. decreased appetite.
d. stomach cramps

Answer 2

a)
depression

Question 3

Following repeated exposure to amphetamine and a short drug-free period, rats exhibit
_________ in sucrose preference that is indicative of withdrawal-induced ___________.
a. a decrease; anhedonia
b. an increase; reward sensitization
c. no change; reward indifference
d. an increase; allostasis

Answer 3

a)
a decrease; anhedonia