Amyloidoses

Question 1

Multiple Myeloma
Major Fibril Protein &
Precursor Protein

Answer 1

AL

Immunoglobulin Light Chains–Lambda type

Question 2

Chronic Inflammatory Conditions
Major Fibril Protein &
Precursor Protein

Answer 2

AA

SAA

Question 3

Hemodialysis & Renal Failure
Major Fibril Protein &
Precursor Protein

Answer 3

Abeta2m

Beta2-microglobulin

Question 4

Familial Mediterranean Fever
Major Fibril Protein &
Precursor Protein

Answer 4

Mutated Pyrin=>inc inflammation
=>inc IL-1=> inc SAA
AA
SAA

Question 5

Familial Amyloidotic Neuropathies
Major Fibril Protein &
Precursor Protein

Answer 5

ATTR

Mutant Transthyretin

Question 6

Systemic senile amyloidosis
Major Fibril Protein &
Precursor Protein

Answer 6

Often involves the heart
ATTR
Normal or mutant Transthyretin

Question 7

Senile Cerebral
Major Fibril Protein &
Precursor Protein

Answer 7

Alzheimer’s disease
Abeta
APP

Question 8

Medullary Carcinoma of Thyroid
Major Fibril Protein &
Precursor Protein

Answer 8

DM II
A Cal
Calcitonin

Question 9

Islets of Langerhans
Major Fibril Protein &
Precursor Protein

Answer 9

DM II
AIAPP
Islet Amyloid Peptide (Amylin)

Question 10

Isolated atrial amyloidosis
Major Fibril Protein &
Precursor Protein

Answer 10

AANF

Atrial natriuretic factor