Anaphylaxis Flashcards Preview

CEN Medical Emergencies > Anaphylaxis > Flashcards

Flashcards in Anaphylaxis Deck (24)
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1
Q

How is it similar to sepsis?

A

Mediator release

2
Q

How is it difference than sepsis?

A

Antigen exposure –> mediator release

3
Q

Initial S/S

A

Hives (from capital permeability from the skin)
Flushing (vasodilation)
Tachycardia

4
Q

Vasodilation causes

A

Hypotension

Mucosal edema/airway (most vasodilation is in upper airway)

Obstruction

5
Q

Capillary permeability causes

A

Hypovolemia

Pulmonary Congestion

6
Q

3 Drugs of choice

A

Bronchodilator (Inhaled Beta - 2 agonists)

Corticosteroids (suppresses inflammatory - prevent delayed reaction)

Antihistamine

7
Q

H1 Blocker

A

Benadryl

8
Q

H2 Blocker

A

Cimetindine, Ranitdaine, Famotidine

9
Q

Mild anaphylaxis characterized by

A

Normal BP

Minimal RD

10
Q

Mild anaphylaxis dosage of EPI

A

IM 1:1,000

11
Q

Severe Anaphylaxis characterized by

A

Hypotension

Severe RD

12
Q

Severe anaphylaxis dosage of EPI

A

IV 1:10,000

Repeat 15-30 mins PRN up to 2 doses

13
Q

What can BB inhibit?

A

The work of EPI in anaphylaxis

14
Q

What can a BB do to the lungs?

A

Vasoconstriction

Bronchospams

15
Q

EPI has both..

A

Alpha-Adrenergic (Vasoconstriciton)

Beta-Adrenergic (Vasodilation)

16
Q

What happens if you give both EPI and a nonselective BB?

A

Non selective BB prevents the vasodilation

Leaving unopposed Alpha vasoconstriction

17
Q

What can be given for pt’s on BB that don’t respond to EPI

A

glucagon

18
Q

IM EPI dosage calculation if you have time..

A

0.01 mg/kg no greater than 5mg for single dose

19
Q

Epi Infants <10kg autoinjector

A

0.1mg or 0.15mg (- if 0.1mg is not avaliable)

20
Q

Epi 10-25kg

A

0.15 mg

21
Q

Epi 25-50kg

A

0.3mg

22
Q

> 50kg

A

0.5mg

23
Q

When can epi be repeated

A

5-15min intervals

24
Q

Epi IV infusion starting rate

A

0.1 mcg/kg/minute increase by 0.05 mcg/kg/minute every 2-3 mins to improve perfusion