Anatomy, Physiology, and Assessments Flashcards
(93 cards)
√What are the embryological precursors of the larynx? What is their blood supply? How do these precursors predict the patterns of laryngeal lymphatic drainage?
Supraglottic Larynx:
- Buccopharyngeal primordium, developed from the 3rd and 4th branchial arches
Glottic and Subglottic larynx:
- Formed by a union of lateral furrows that develop on each side of the tracheobronchial primordium, developed from 6th branchial arch
Blood Supply (dual) & Lymphatic drainage:
Supraglottis:
- Blood supply: Superior laryngeal arteries (from the superior thyroid artery > external carotid)
- Lymphatics follows the arteries down to the carotid sheath to drain into deep cervical chain nodes in level II & III
- Lymphatics drain bilaterally (b/c supraglottis forms as a whole with no fusion in the midline, unlike glottis/subglottis)
Glottis & Subglottis:
- Blood supply: Inferior laryngeal arteries (originating from the inferior thyroid artery > thyrocervical trunk > subclavian artery)
- Lymphatics follows the arteries to drain into the prelaryngeal and pretracheal nodes (level VI) before reaching the deep cervical chain nodes in level IV
- Glottis is formed by paired structures (union on each side of primordium) that fuse in midline. Lymphatics thus drain unilaterally and vocal folds have sparse lymphatics
- Glottic cancers must invade deeply before accessing lymphatics. Hence - Low incidence of LN mets and propensity for unilateral mets
√Outline the Embryology of the Larynx
- 4 weeks: Formation of the laryngotracheal groove in the ventral wall of the primitive pharynx
- 5-7 weeks: Elongation of the laryngotracheal diverticulum, separated from the dorsal foregut by the tracheoesophageal septum
- 8-9 weeks: Epithelial proliferation obliterates the laryngeal lumen
- 10 weeks: Recanalization of the laryngeal lumen is complete
https://c8.alamy.com/zooms/9/6ca683aed6cb4a8f9ad5e47b57914608/2hcj0ep.jpg
√Name the boundaries and subsites of the supraglottis, glottis, and subglottis.
What are the 5 subsites of the supraglottis?
Supraglottis Boundaries:
- Superior: Superior surface of epiglottis, hyoepiglottic ligament, AE folds
- Inferior: two definitions: (1) Midpoint of laryngeal ventricle, or (2) Superior most limit of the true vocal fold
- Anterior: Thyrohyoid membrane, thyroid cartilage
Supraglottis Subsites:
- Aryepiglottic folds
- False vocal folds
- Suprahyoid epiglottis
- Infrahyoid epiglottis
- Arytenoids
Glottis Boundaries:
- Superior: same as inferior supraglottis
- Inferior: 1cm below superior limit
- Anterior: Thyroid cartilage
Subglottis:
- Superior: 1cm below imaginary line described above
- Inferior: Inferior border of cricoid
- Anterior: Cricothyroid membrane, cricoid cartilage
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√Describe the Epithelial linings of the larynx.
What are the areas that are rich in glands? 4
Supraglottis:
- Epiglotiss, lingual surface: Non-keratinizing, stratified squamous cell epithelium (SSCE)
- Epiglottis, laryngeal surface - upper half and lateral borders SSCE, lower half respiratory (ciliated pseudostratified columnar epithelium with globlet cells)
- False fold: Respiratory epithelium (Pseudostratified columnar epithelium)
- Edges of the AE folds = stratified squamous epithelium
Glottis:
- Floor to ventricle to subglottis: Non-keratinizing Stratified squamous epithelium
- Anterior and posterior commissure: respiraotry epithelium
Subglottis:
- Respiratory epithelium - Pseudostratified columnar epithelium
Areas that are rich in glands:
- Ventricle
- Saccule
- Anterior and posterior commissure
- Subglottis in kids
√Describe the lymphatic drainage patterns of the larynx
Supraglottis: Bilateral II, III, IV
Glottis: Sparse lymphatics, metastasis rare unless deep invasion. (VI first if reached)
Subglottis: Commonly unilateral, can involve VI (III, IV, VII possible)
What are two paired joints of the cricoid?
- Cricoarytenoid
- Cricothyroid
Describe the cricoarytenoid unit. What is its importance?
Cricoarytenoid unit
= the functional unit of the larynx
= at least 1 arytenoid + its attachment to the cricoid
Significance: At least one cricoarytenoid unit is needed to maintain speech and swallowing without a tracheostomy
What are the cricoarytenoid joint stabilizers?
- Posterior cricoarytenoid ligament
- Fibrous articular capsule
- Vocal ligament
Describe the borders of the Quadrangular Membrane. What is its significance?
Quadrangular Membrane
= Ligament that forms the AE folds and the false vocal folds
= Forms the superior border of the paraglottic space
Borders:
- Superior (free margin): AE fold
- Inferior: Vestibular ligament (of false vocal folds)
- Posterior: Arytenoid, corniculate, cuneiform
- Anterior-Superior: Lateral margin of epiglottis
- Anterior-inferior: Thyroid alae
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Vancouver 169
https://www.researchgate.net/profile/Jonathan-Wisco/publication/360266219/figure/fig1/AS:11431281094515081@1667483490719/Hemisected-view-of-the-larynx-The-thyroepiglottic-thyrohyoid-hyoepiglottic-and.png
Describe the Conus Elasticus. What is its significance?
Conus Elasticus
= Ligament that forms the vocal ligament
= Forms the inferior border of the paraglottic space
= Connects the cricoid cartilage with the thyroid and artyenoid cartilages, composed of dense fibroconnective tissue with abundant elastic fibers
Borders:
- Inferior: Attaches to cricoid cartilage
- Supero-Anterior: Attaches to anterior commissure at thyroid
- Supero-Posterior: Vocal process
- Superior free edge: Becomes the vocal ligament
- Anterior: continuous with cricothyroid membrane
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https://www.researchgate.net/profile/Camille-Finck/publication/6776751/figure/fig7/AS:601796301053963@1520490827232/Laryngeal-cartilages-and-conus-elasticus-From-SOBOTTA-Atlas-dAnatomie-humaine-Ferner.png
What is Broyle’s Ligament? What is its significance
Broyle’s Ligament
= Ligament connecting the anterior commissure to the thyroid cartilage
= Lacks perichondrium, so provides a point of invasion into the thyroid cartilage and pre-epiglottic space
https://image.slidesharecdn.com/anatomyoflarynx-180222171335/85/anatomy-of-larynx-45-320.jpg?cb=1665658829
What is the petiole?
Triangular point at the base of the epiglottis where the thyroepiglottic ligament attaches to the thyroid cartilage
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What is the angulation of the thyroid prominence?
Male - 120 degrees
Female - 90 degrees
√What are the attachments of the superior, middle, and inferior constrictor muscles?
SUPERIOR:
1. Skull base
2. Pterygomandibular raphe
3. Medial pterygoid plate
4. Mylohyoid line
5. Base of tongue
“Sue Me Punch My Base of tongue”
MIDDLE:
1. Stylohyoid ligament
2. Hyoid bone
INFERIOR:
1. Thyroid cartilage
2. Cricoid cartilage
Describe the boundaries, lymphatic drainage, and contents of the pre-epiglottic space. What is its significance? What is another term for the space?
Aka. Boyer’s space
Superior: Hyoid bone, Hyoepiglottic ligament, and valleculae mucosa
Anterior: Thyrohyroid membrane and thyroid cartilage
Posterior: (Infra-hyoid) Epiglottal cartilage and the thyroepiglottic ligament (posterior-inferior interface between pre-epiglottic space and paraglottic spaces)
Inferior: Lower portion of the hyoid bone until mid-portion of thyroid cartilage; thyroepiglottic ligament
Lateral: Open - continuous with the paraglottic spaces
Lymphatic Drainage: through thyrohyoid membrane and spread bilaterally to LN in Level II & III
Contents: Fat and areolar tissue
Significance:
- Involvement of the PES allows for spread into the paraglottic space (involvement of either entity upstages to T3)
- Easily invaded by an infrahyoid epiglottis mass due to fenestrations in the epiglottic cartilage
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Describe the boundaries of the para-glottic space. What is its significance? What is another term for the space?
Aka. Tucker’s space
Space that is lateral to the true&false cords and extends laterally to the thyroid cartilage (space between the thyroarytenoid muscle and cartilage)
Borders:
- Medial (from superior to inferior): Quadrangular membrane, Laryngeal ventricle, Conus Elasticus (lateral portion of the cricothyroid membrane, that comes up and forms the vocalis muscle)
- Lateral: Thyroid cartilage (anterior), Mucosa of medial wall of the piriform sinus (posterior)
- Inferolateral: Cricothyroid membrane
- Superior/anterior: Continuous with PES
- Posterior: Pyriform sinus
Significance: Extension into the PGS allows for spread into any of the 3 subsites of the larynx
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Vancouver 170
What are the borders of the pyriform sinus?
- Medial: aryepiglottic cords
- Lateral: thyroid cartilage
- Posterior: low pharyngeal wall
Discuss the normal length of the vocal folds in infants, adult males and females
Infant = 7-8mm
Male = 17-23mm
Female = 12-17mm
What are the layers of the vocal fold from superficial to deep?
- Epithelium (stratified squamous)
- Superficial lamina propria
- Intermediate lamina propria
- Deep lamina propria
- Vocalis muscle
*ILP + DLP = Vocal ligament
What are the cell types of each of the layers of the vocal folds?
- Epithelium (stratified squamous)
- Mucosal layer
- Stratified non-keratinizing squamous epithelium - Superficial lamina propria
- Few fibroblasts
- Scant elastic and collagen fibers - Intermediate lamina propria
- Mainly elastic fibers, few fibroblasts - Deep lamina propria
- Collagenous fibers, fibroblasts - Vocalis muscle
Vancouver 168
Describe Reinke’s space and list two points of significance for this space
Reinke’s space = Space between the vocal ligament and the epithelium of the vocal fold (ie. the SLP).
Clinical Significance:
1. Fluid can accumulate here causing Reinke’s edema
2. Gelatinous matrix within Reinke’s space allows for vocal folds to vibrate freely
Differentiate the laryngeal vestibule from the laryngeal ventricle
Vestibule = The laryngeal inlet to the superior or surface of the false vocal cords
Ventricle = The pouch between the true and false vocal cords
√List the 6 different extrinsic laryngeal elevators and their innervations
Suprahyoid musculature (5):
1. Anterior belly of digastric (V3)
2. Posterior belly of digastric (VII)
3. Mylohyoid (V3)
4. Geniohyoid (C1 carried by hypoglossal nerve)
5. Stylohyoid (VII)
Sylopharyngeal (IX)
√List the 4 different extrinsic laryngeal depressors and their innervations
Strap muscles (4)
1. Omohyoid (Ansa, C1-3)
2. Sternohyoid (Ansa, C1-3)
3. Sternothyroid (Ansa, C1-3)
4. Thyrohyoid (Ansa, C1 only)
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