Anemia Megaloblástica Flashcards

1
Q

Cómo se produce?

A

Por defecto en síntesis de ADN producto del deficit de vit b12 y ácido fólico

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2
Q

Que tipo de anemia es?

A

Macrocitica, son hiporregenerativas o arregenerativas por descenso de reticulocitos
Con VCM mayor 110 fl

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3
Q

Dónde se absorbe la vit b12?

A

Ileon terminal

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4
Q

Cuando deplesiona?

A

1000 días

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5
Q

Depósito de vit b12?

A

2 a 5 mg en hígado y riñón

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6
Q

Absorción de ácido fólico?

A

Yeyuno

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7
Q

Depósito y deplecion de ácido fólico?

A

5 a 10 mg
Depleciona a 100 días

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8
Q

Que deficit es más frecuente, ácidos fólico o cobalamina?

A

De acido fólico porque las necesidades son mayores

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9
Q

Necesidades de cobalamina y ácido fólico?

A

B12: 2 a 5 mcrogr/día
B9: 50 a 100 mcgr/día

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10
Q

Causas de anemia por ácido fólico?

A
  1. Disminución de ingesta
  2. Disminución de absorción
  3. Aumento de requerimientos
  4. Aumento de perdidas
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11
Q

Manifestaciones clínica de anemia por deficit de vitamina b12?

A

Tríada clásica: palidez flavinica, glositis y parestesia

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12
Q

Cuándo se sospecha de anemia por deficit de vit b12 y ácido fólico?

A
  1. Macrocitosis
  2. Síntomas neurológicos
  3. Dieta vegana, cirugía bariátrica, desnutrición
  4. Anorexia
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