Anemias I Flashcards Preview

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Flashcards in Anemias I Deck (19):
1

Definition of Anemia

A decrease in the circulating red blood cell (RBC) mass

2

Usual Criteria for anemia

(Men Hgb and HCT, Wonem Hhb and HCT)

Women: Hgb<12 g/dl, Hct<35%

Men: Hgb<14 g/dl

 

 

3

The usual ratio of Hgb to Hct is

1:3

4

Definition of hematocrit

The volume of packed RBCs

5

Definition of hemoglobin

the molecule which binds and transports oxygen

6

Constituents of hemoglobin

Heme: protoporphyrin and iron

Globin: the protein portion

7

What is the lifespan of one meager red blood cell?

120 days

8

What happens to "old RBCs"?

they are removed by the spleen

9

What are the normal ranges for Hgb and Hct in males and females?

Hemoglobin:

male: 14-18 g/dl

female: 12-16 gdl

Hematocrit:

male: 40-50%

female: 35-45%

(but do note that these ranges can vary a bit from lab to lab)

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11

How is an RBC formed? (answer is looking for a series of steps)

most immature RBC is a pronormoblast

pronormoblast->nucleated RBCs->then the nucleus disintegrates forming the immature cell called the "reticulocyte"

reticulocytes are released into the bloodstream and mature into RBCs in 1-2 days

 

12

What is the retic count?

an indication of RBC production

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14

How would one go about finding a retic count?

Rectics stain blue on smear

"Lots of blue means lots of new"

15

Normal rectic count?

.5-2.5%

16

What is polychromasia?

aka: reticulocytosis

(while nothing else is addressed on this slide's test, it may be best to recall that polychromasia aka reticulocytosis refers to an overabundance or RBCs and there are generally 3 recognized forms.. may be addressed later?)

17

What are 3 causes of anemia?

1. decreased RBC production (could be due to iron deficience, B12 or folate deficiency or chronic disease)

2. Increased RBC destruction (due to hemolysis)

3.  Blood loss (menstural, GI bleeding, trauma)

18

How is RBC size determined?

by viewing a peripheral blood smear under microscope

OR

by viewing a computerized value granted to you by a machine

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