Angina 01.15 Flashcards
(22 cards)
Acute Coronary Syndrome (ACS) initial treatment of MONA:
Morphine
Oxygen
Nitrates (GTN)
Aspirin
Secondary prevention of ACS - MI5 - what is this?
- Aspirin
- Clopidogrel
- Ace inhibitor
- Beta blocker
- Statin
SE of aspirin
GI irrit / bleed
Bronchospasm
Tinnitus
This drug - metabolised by CYP450 - inhibits platelet action & has similar SE to aspirin
Clopidogrel
Interactions of clopidogrel
Fluoxetine
PPIs
Enzyme inducers (carbamezapine)
SE of ace inhibitor eg ramipril
Cough
Hyperkalaemia
Renal & hepatic impairm
Interaction of ace inhibitors 2
Diuretics (-drop BP)
Nephrotoxic drugs
Beta blocker (atenolol) SE (4)
Bradycardia
Cold - raynauds
Bronchospasm
Sexual dysfunction
Interaction of beta blocker with these causes heart block
Calcium channel blockers - Verapamil & Ditiazem
Statins - SE (3)
Headache
Myalgia
Altered liver function
This drug inhibits HMG CoA Reductase, lowering LDL-C levels and enabling liver to remove LDL-C
Statins eg simvastatin
Interactions of statins
Enzyme inhibitors eg Grapefruit juice & clarithromycin
GTN releases what, which incr cGMP and causes vasodilation
Nitric Oxide
GTN s/e
Headache
Hypotension
GTN Contraindications 2
Hypotension
Aortic & mitral stenosis
Contraindication of beta blockers 2
Asthma & bradycardia
This is a K channel activator - causing vasodilation by reducing Ca entry into cell and acting as an NO donor (3rd line treatment)
Nicorandil
Contraindications of nicorandil (2)
Left ventricular failure
Hypotension
SE of nicorandil (3)
Headache
GI irritibility
Hypotension
This disease results in increased RBCs and blood viscosity - risk of strokes & incr BP
Polycythaemia rubra vera
Amlodipine, nifedipene, felodipine are what class of drug?
Ca++ channel blockers
This drug causes smooth muscle relaxation (vasodilation) by inhibiting influx of Ca++
Ca++ channel blockers
