angioedema

Question 1

characteristics of angioedema

Answer 1

acute edema of SC tissue- not itchy and resolve over hours to several days

Question 2

Mng of angioedema

Answer 2

Less sedating antihistamines - daily preferred over PRN
If higher doses of less sedating antihistamines dont work , add monteleukast

If symtpoms severe, persistent, distressing -> PO prednisolone

Question 3

SFX monteleukast

Answer 3

Neuropsychiatric SFX - behavioural, depression, suicidality

Question 4

Types of angioedema

Answer 4

With urticaria
Without urticaria -> two subtypes: ACEi induced and hereditary - both caused by raised bradykinin rather than histamine

Question 5

What meds should be avoided in patients with hereditary angioedema

Answer 5

ACEI
Estrogen containing contraceptives

Question 6

Differentiating between bradykinin and histamine mediated angiodema

Answer 6

Bradykinin mediated would not show response to antihistamines

Question 7

What meds does bradykinin mediated angioedema respond to

Answer 7

TXA
Icatibant
Purified C1 esterase inhibitor
lanadelumab