Animal Models Flashcards by Sally Makhija

Brown Norway (non agouti brn)

Rat

Hydronephrosis
Inducible, transplantable myeloid leukemia
Bladder carcinoma

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ACI (agouti, wht belly and feet)

Rat

Congenital genitourinary anomalies
Agenisis of R kidney
High incidence of testicular tumors

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BB/Wor (same as BB/Wistar)

Rat

Juvenile insulin-dependent DM

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BUF (albino)

Rat

Spontaneous autoimmune thyroiditis (Hashimoto’s dz)
Other models are: BUF, BB wistar, mult mammate rat, Beagle dog, obese chicken, marmoset

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COP (Copenhagen) brn hooded

Rat

prostate adenocarcinoma

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F-344 (albino)

Rat

Toxicology work

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LEW (Lewis) albino

Rat

Mult. sclerosis, autoimmune dz

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LOU/C

Rat

Myeloma, production of IgG autoantibody

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SHR (spontaneous Hypertensive Rat) albino

Rat

Hypertension, cardiovascular researsh

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WF(wistar furth) albino

Rat

Mononuclear cell leukemia

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Zucker

Rat

obesity

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Brattleboro (blk hood)

Rat
diabetes insipidus (auto recessive)

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Gunn (albino)

Rat

jaundice, kernicterus. Remember “GUS”

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Nude

Rat

T-cell deficient (auto recessive)

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Obese SHR

Rat

Type 4 hyperlipoproteinemia (auto recess.)

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Long Evans Cinnamon

Rat

Wilson’s dz (cu storage dz) other models are: white perch, bedlington terrier. Use Rubeanic acid stain to detect Cu.

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Japanese spaniel

Dog

GM gangliosidosis

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Carin terrier

Dog
Krabbs dz (globoid cell leukodystrophy)

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Basenji

Dog

Pyruvate kinase deficiency

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Alaskan malamute

Dog

Human inherited hemolytic anemia factor VII and achondroplasia

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Kerry Blue terrier

Dog

Spiculosis, Factor XI deficiency

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Weimaraner

Dog

Syingmyelia

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Bedlington terrier

Dog

Wilson’s dz(Cu storage dz) (also: LEC rats, holstein cows, white Pearch, sheep)

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Irish setter

Dog

Leukocyte adhesion deficiency (also: holstein cows, Cd18- mice)

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Gray collies

Dog | cyclic hematopoiesis

Golden retrievers

Dog | Duchenne muscular dystrophy

blue smoke persian, and beige mouse

Cat | Chediak-Higashi syndrome

Siamese

Cat | GM1 gangliosidosis, Wilson's dz, Sphingomyelinosis (Neimann-Pick)

male tortoiseshell

Cat | Klinfelter's syndrome (XXY)

Norwegian forest cat

Cat | Glycogen storage disorders

Mane coon cats

Cat | Hypertrophic cardiomyopathy

Manx cats

Cat | Spina biffida

corriedale breed (Pneumonic = CDC)

Ruminant | Congenital hyperbilirubinemia/hepatic organic anion excretory defect (Dubin-Johnson Sydrome) (conjugated)

southdown breed (Pneumonic=GUS2)

Ruminant congenital hyperbilirubinemia/hepatic organic anion uptake defect (Gilbert syndrome) (unconjucated) (also squirrel monkey

dorset breed

Ruminant | glucose-6-phosphate dehydrogenase deficiency

Fainting goats

Ruminants inherited caprine myotonia congenita (Fainting goats) human mytonia congenita (Thomsen's dz)

Holstein cows

Ruminant | Leukocyte adhesion deficiency

Japanese Madaka (Oryzias latipes)

FIsh | carcinogenesis, toxicology

White perch (Merone americana)

Fish | Wilson's dz (Cu storage dz)

Fathead minnow (Pimephales promelas)

Fish | EPA tox testing

Bicolor Damselfish (Pomacentrus partitus)

Fish | Von Recklinghousen's dz (neurofibromatosis) can also be induced in hamsters with ENU

Rainbow trout (Oncohynchus mykiss)

Fish | carcinogenesis

Carp (Cyprinus carpio)

Fish | Diabetes mellitus

Platyfish (Xiphophorus spp.)

Fish | Malignant melanoma

Walleye (Stizostedion vitreum)

Fish | Dermal sarcoma

Spontaneous: | Heredititary hyperbilirubinemia, Crigler hajjar syndrome = kernicterus

Spontaneous | Gunn rat

Spontaneous: | GUS2

Spontaneous | Gunn/Gilbert, Unconj/imparred Uptake, Squirrel monkey/Southdown sheep

Spontaneous: | CDC

Spontaneous | Conj, Dubin johnson, Coriedale

Spontaneous: | aganglionic megacolon

Spontaneous | Piebald lethal, lethal spotting mice

Spontaneous | Type I DM

Spontaneous | NOD nonobese, diabetic mouse, BB wistar

Spontaneous: | SLE, glumerulonephritis autoimmune dz

Spontaneous | NZB, NZW mice

``` Spontaneous Digeroge syndrome (congenital thymic aplasia) ```

Spontaneous | Nude mice

Spontaneous: | severe combined immunodeficiency

Spontaneous | SCID mice

Spontaneous: | hypercholesterolemia

Spontaneous | Watanabe rabbits

Spontaneous: | neurogenic DM

Spontaneous | Battleboro rats

``` Spontaneous: Hashimotos thyroiditis (autoimmune thyroiditis) ```

Spontaneous | Obese chicken, BUF rat, BB wistar, mult mammate rat, Beagle, marmoset

Spontaneous: | primary hypertension

Spontaneous | SHR rat

Spontaneous: | Duchenne muscular dystrophy (X linked)

Spontaneous | golden retriver, mice, hamsters

Spontaneous: | hemophilia A and B

Spontaneous | Dog

Spontaneous: | Chediak- Higashi syndrome

Spontaneous | Blue persian cats, mink, Beige mouse,

Spontaneous: | Wilson's dz/Cu storage

Spontaneous | Long Evan's Cinnamon, Bedlington terrier, Siamese cat, White perch (Merone americana)

Spontaneous: | Leukocyte adhesion deficiency

Spontaneous | Holstein cows, Irish setters, CD 18, LEC rats

Induced: | Alloxin

insulin dependent DM, destroy beta cells of the islets of langerhans

Induced: | Streptozotocin

insulin dependent DM, destroy beta cells of the islets of langerhans

Induced: | MPTP

parkinson's dz, destroys dopamine producing cells in the brain

Induced: | Hu-SCID mouse

RAG1 gene mutation prevents T and B cell antigen receptor rearrangement, SCID injected with human lymphocytes adopts the human immune system

Nude mouse

Chrom 11, lacks T cell function, tumor and xenograph, Digeorges syndrome

SCID mouse

Chrom 16, lacks T and B cells, gene = Prkdc

Rag 1 and Rag 2

Chrom 2, lacks T and B cells,

XID mouse

Chrom 14, lacks B cells, X linked

Piebald mouse

Chrom 14, gene = Ednrb, aganlionic megacolon

Mouth eaten mouse

Chrom 6, Lacks T and NK cells

Beige mouse

Chrom 13 lacks NK cells, Chediak-Higashi syndrome

LP mouse

Loop tail , audiogenic seizures, neural tube defect

CD18 mouse

leukocyte adhesion, also Irish setters, holstein cattle

RCS

Rat | Royal college of Surgeons, fawn hooded

Animal Models Flashcards

(76 cards)