Anithypertensives

Question 1

Name the ACE inhibitors

Answer 1

Lisinopril, captopril, enalapril

Question 2

Clinical uses of ACEI

Answer 2

Hypertension, heart failure, following MI, renal insufficiency

Question 3

Side effects of ACEI

Answer 3

Severe hypotension, acute renal failure, hyperkalemia, angioedema and dry cough. No pregnancy use.

Question 4

Name ANG II type I blockers

Answer 4

Valsartan, losartan, candesartan, irbesartan, telmisartan

Question 5

Name beta blockers

Answer 5

Non selective : propranolol, pindolol, carvedilol
B1 selective: atenolol, bisoprolol, metoprolol XL
Mixed: Nebivolol

Question 6

Beta blockers clinical use

Answer 6

Hypertension, cardiac failure, following MI, abnormal heart rhythm, anxiety disorders

Question 7

Side effect beta blockers

Answer 7

Hypotension, bradycardia, AV nodal block, reduced exercise capacity, bronchoconstriction, beta blocker blues

Question 8

Name calcium channel blockers.

Answer 8

Covered in drugs for IHD

Question 9

Name diuretics

Answer 9

Thiazides (hydrochlorothiazide, indapamide)

Question 10

Diuretics clinical use

Answer 10

Hypertension, congestive HF, nephrolithiasis due to idiopathic hypercalciuria, nephrogenic diabetes insipidus

Question 11

Side effects of diuretics

Answer 11

Hypokalaemic metabolic alkalosis, Hyponatraemia, Hyperuricaemia, Hyperglycaemia, Hyperlipidaemia, Hypercalcaemia

Question 12

Second line anti hypertensives

Answer 12

Hydralazine, mineralocorticoid receptor antagonist, alpha adrenergic antagonist (Prazosin, Alfuzosin, Terazosin)