Ans

Question 1

Selective M1 antagonist

Answer 1

Pirenzepine & telenzepine

Question 2

Selective M2 antagonist

Answer 2

Methoctramine & Tripitramine

Question 3

Selective M2 agonist

Answer 3

Methacholine

Question 4

Selective M3 agonist

Answer 4

Bethanechol

Question 5

M3 antagonist

Answer 5

Darifenacin & solefenacin

Question 6

Nm receptor agonist

Answer 6

PTMA

Question 7

Nm receptor antagonist

Answer 7

Tubocurarine

Question 8

Nn receptor agonist

Answer 8

DMPP

Question 9

Nn receptor antagonist

Answer 9

Hexamethonium

Question 10

Pilocarpine used as

Answer 10

1. Rx open angle glaucoma (3rd choice)
2. Miotic to counteract midriatic used for refraction test
3. Break irido-lens & irido-corneal adhesions

Question 11

AntiChe in Alzheimer’s

Answer 11

Rivastigmine, donepezil, galantamine

Question 12

First line drugs in myasthenia gravis

Answer 12

Neostigmine, physostigmine

Question 13

Myasthenia crisis is managed by

Answer 13

Tracheal intubation & mechanical ventilation

Question 14

Edrophonium use

Answer 14

Diagnosis of myasthenia gravis

Question 15

Varenicline is

Answer 15

a4b2 subtype Nicotine receptor agonist

Used in smoking cessation

Question 16

Contraction of dilator pupillae

Answer 16

Adrenergic agonists (Active mydriasis )

Question 17

Relaxation of dilator pupilae

Answer 17

Adrenergic blockers (passive miosis )

Question 18

Uses of AntiChesterases

Answer 18

1 Miotic 2. Myasthenia gravis 3. Post-op paralytic ileus/ urinary retention 4. Postop decurarization 5. Alzheimer’s 6. Belladona poisoning 6. Drug overdose ( TCA, antihistamines)

Question 19

Opp poisoning Rx

Answer 19

1. Atropine 2. Pralidoxime 3.wash skin, lavage, patent airway,BP,hydration, convulsions

Question 20

Antich esterases used in Alzheimer’s

Answer 20

Rivastigmine,Donepezile, Galantomine

Question 21

Rx myasthenia gravis

Answer 21

1. Neo/ pyridostigmine
2. Thymectomy
3. Glucocorticoid
4. Immunosuppressant
5. Plasmapheresis

Question 22

Muscarinic side effects

Answer 22

S salivation
L lacrimation
U urinary incontinence 
D diarrhoea
G hi distress
E emetics
Bradycardia 
Miosis

Question 23

Atropine poisoning Rx

Answer 23

Gastric lavage with tannic acid
Keep in dark quite room
Rest Rx mostly symptomatic
Or neostigmine (but cns effects aren’t antagonized)
Or physostigmine (but s/e hypotension arrhythmia)

Question 24

Smoking cessation Rx

Answer 24

1. Nicotine patch or chewing gum
2. Varenicline (partial NR agonist)
3. Buproprion (antidepressant)

Question 25

Action of b1 on kidney

Answer 25

Renin release

Question 26

a1 agonist

Answer 26

Phenylephrine

Question 27

a2 agonist

Answer 27

Clonidine

Question 28

a1 antagonist

Answer 28

Prazosin

Question 29

a2 antagonist

Answer 29

Yohimbine, Rauwolscine

Question 30

b1 agonist

Answer 30

Dobutamine

Question 31

b2 agonist

Answer 31

Salbutamol , terbutaline

Question 32

B1 antagonist

Answer 32

Metoprolol, atenolol

Question 33

B2 antagonist

Answer 33

Propranolol (non selective)

Question 34

B3 agonist

Answer 34

Mirabegron

Question 35

A2 action on platelet

Answer 35

Aggregation

Question 36

A2 on insulin release

Answer 36

Decreases insulin release

Question 37

B2 on insulin release

Answer 37

Stimulates insulin release

Question 38

S/E of nasal decongestant like naphazoline

Answer 38

``` Initial stinging sensation, Anosmia Impaired muco-ciliary function Atrophic rhinitis Systemic s/e like cns depression, HTN ```

Question 39

Orally active alpha adrenergics

Answer 39

Ephedrine & Mephenteramine (resistant to mao)

Question 40

Rx amphetamine toxicity

Answer 40

Chlorpromazine

Question 41

Persistent/postural hypotension Rx

Answer 41

Adequate hydration, electrolyte balance & elastic stockings

Question 42

Non selective b blockers+ a blocking property

Answer 42

Labetelol & carvedilol

Question 43

Membrane stabilising property in

Answer 43

Propranolol, acebutolol & oxprenolol

Question 44

A/E of b blockers

Answer 44

Cns: nightmares, forgetfulness, lack of drive CVS: bradycardia,hypotension, heart block RS: ppt asthma bronchoconstriction Metabolic: masking of symptoms of hypoglycaemia,dyslipidemia BV: reduced exercise capacity, tiredness, worsening of pvd, Erectile dysfunction

Question 45

Acute glaucoma Rx

Answer 45

1. Mannitol 20% or glycerol(10%) 2. Acetazolamide (0.5G) 3. Pilocarpine (1-4% every 10 minutes) 4. Timolol 0.5% 5. Apraclonidine/ Latanoprost may be added

Question 46

K+ blocking b blocker

Answer 46

Sotalol

Question 47

B blockers with shortest duration of action

Answer 47

Esmolol

Question 48

Intrinsic sympathomimetic activity in which b blockers

Answer 48

Pindolol, Acebutolol, Celiprolol

Question 49

Which b blockers have ccb activity

Answer 49

Carvedilol and betaxolol

Question 50

B blockers with NO release property

Answer 50

Celiprolol and nebivolol