ANS

Question 1

ANS

Answer 1

Parasympathetic- Periphery NS, Autonomic, CIII, VII, IX, X, S2-S4
Sympathetic- Periphery NS, Autonomic, T1-T12, L1-L5, may Sacral
Under unconscious controll
Afferent- Away/Activity to CNS
Efferent- Exit/ Effects to Periphery (smooth muscle, cardia, exocrine

Question 2

Somatic receptors and TMs

Answer 2

NT- AcH
Receptor- Nicotinic
Skeletal muscles
NO Ganglions

Question 3

PSNS receptors and TMs

Answer 3

Cranial and Sacral
PSNS-Presynaptic/Preganglion: LONGER
NT- ACH,
Receptor- Nicotinic.

Postsynaps/Postganglion: Shorter closer to organs (cardia, smooth muscle, gland,
NT-ACH, Receptor- Muscunaric

Question 4

SNS receptors and TMs

Answer 4

Presynaptic/Preganglion: Shorter very close to ganglion
NT- ACH,
Receptor: Nicotinic ganglion

Postsynaps/Postganglion: Longer
Sweat Glands-NT-ACH, Receptor- Muscarinic

NT-EPI, NE, ACH, Receptor-Nicontinic on Adrenal medulla

Cardiac, smooth muscle, glands
NT-NE
Receptor- Alpha and Beta

Renal, vessels-
NT-NE, Dopamine
Receptor- Alpha1 or Dopamine1

Question 5

PSNS

Answer 5

Rest and digest
NT- ACH
AKA Cholnergic
Receptors- M1-M5

ACH-synthezies in vessecal via cholin acetylyintranferase
Acetycholnieresrase- breaks down ACH at synaptic cleft

Question 6

PSNS on Eye

Answer 6

Agonist (or ACH RX) effect on Muscarinic receptor
Iris spincter (CN III) constricts miosis pupil
Iris radial- no effect
Cillary- contracts, lens relaxed/shorten for near vision

Think PS relax, no danger to see clear or far.

Question 7

PSNS Heart

Answer 7

Agonist (or ACH RX) effect on Muscarinic receptor
SA node- decelarates
Contracil-decrease

Question 8

PSNS Blood Vessels

Answer 8

Agonist (or ACH RX) effect on Muscarinic receptor
releases endothelium derived relaxin factor
Vasodialtion

Relaxed/Rest- Blood flow everywhere

Question 9

PSNS Bronchial

Answer 9

Agonist (or ACH RX) effect on Muscarinic receptor
smooth muscles- contracts
Glands- sercrete
Rest- all working

Question 10

PSNS GI

Answer 10

Agonist (or ACH RX) effect on Muscarinic receptor
inc. motility and tone
relaxes sphincter
increase secretion
ADE- diaharreah

Question 11

PSNS Bladder

Answer 11

Agonist (or ACH RX) effect on Muscarinic receptor
Detrusor- contracts (squeeze pee out)
Trigone spincter- relaxers (opens)

Question 12

PSNS Salivary/Lacrimal glands/sweat Glands

Answer 12

Agonist (or ACH RX) effect on Muscarinic receptor

Secretions

Question 13

PSNS Kidney

Answer 13

Agonist (or ACH RX) effect on Muscarinic receptor

NONe

Question 14

PSNS Uterus

Answer 14

Agonist (or ACH RX) effect on Muscarinic receptor

Contracts

Question 15

PSNS GU

Answer 15

Agonist (or ACH RX) effect on Muscarinic receptor

Erection

Question 16

PSNS Liver, Fat

Answer 16

Agonist (or ACH RX) effect on Muscarinic receptor

Question 17

PSNS Pancreas

Answer 17

Agonist (or ACH RX) effect on Muscarinic receptor

Question 18

SNS on Eye

Answer 18

Agonist (or RX) effect on Alpha Beta receptor
A1 radial contracts smooth muscle, mydriais (dialtion
B1 B2- relaxes cilary muscle- far vision

Question 19

SNS Heart

Answer 19

Agonist (or RX) effect on Alpha Beta receptor

B1 B2- increase rate and contraction

Question 20

SNS Blood Vessels

Answer 20

Agonist (or RX) effect on Alpha Beta receptor
Coronary
A1 A2- constricts B2- dilates

Renal
A1 A2- constricts, B1 B2- dilates

Skeletal
A1A2- constricts, B2- dilates

Veins
A1 A2- constricts B2- dilates

Question 21

SNS Bronchial

Answer 21

Agonist (or RX) effect on Alpha Beta receptor
A1 glands dec secretions, B2-inc
B2-relax

Question 22

SNS GI

Answer 22

Agonist (or RX) effect on Alpha Beta receptor
A1 A2
B1 B2

Question 23

SNS Bladder

Answer 23

Agonist (or RX) effect on Alpha Beta receptor
Detrusor
B23-relaxed
Trigone Spinc
A1- contraction

Question 24

SNS sweat glands

Answer 24

Agonist (or RX) effect on Alpha Beta receptor

A1 - secretions

Question 25

SNS Kidney

Answer 25

Agonist (or RX) effect on Alpha Beta receptor Renin secretion A1- decreased B1- increase Ureters-A1 increase tone smooth mus

Question 26

SNS Uterus

Answer 26

Agonist (or RX) effect on Alpha Beta receptor A1- contractions B2- relaxation

Question 27

SNS GU | Skeletal

Answer 27

Agonist (or RX) effect on Alpha Beta receptor A1 -Ejaculations Skeletal B2-contract, glyogenolyisis

Question 28

SNS Liver, Fat

Answer 28

Agonist (or RX) effect on Alpha Beta receptor A1, B2- glycogenolyis, gluconeogenesis (Inc. DM) Fat A1B13- lypolysis

Question 29

SNS Pancreas

Answer 29

Agonist (or RX) effect on Alpha Beta receptor A1 A2- dec secretions B2-inc. secretions

Question 30

PSNS RX PSmimetics (mimic PSNS) | Cholinesterase inhibitors

Answer 30

``` Stem "chol" INDIRECT ACTs ON ACETYCHOLINESTERASE INHIBITORS thus limits this enzyme to break down ACH. T ACH is INCREASED SLUD...ADE SALVIATION LACRIMATIN URINATION DIARRHEA ```

Question 31

Asthma

Answer 31

anticholerngic to decrease secretions, but stimulate SNS (fight or flight) not relaxed, no wonder attacks

Question 32

Parasympatholytics

Answer 32

``` lysis of PNS, dec ACH, get SNS resutls ANTICHOLINERGIC EFFECT USED preop-dec salivation, secretons, improve bradycardia Direct acting ANTAGONISTS ON M1-M5 RECEPTORS dry mouth mydriasis- constricted pupil skin hot CNS confusion constipation Airway dialtion, secretion reduced Urinary retention Tachycardia ADE- DRY AS A BONE, BLINDA AS A BAT, RED AS A BEET, MAD AS A HATTER ``` CONTRA- GERD (SLOW EMPTY, ACID SITS) GLAUCOME, URINARY RENTION, DEMENTIA

Question 33

Sympathetic NS Ergotrophic Andrenergic System

Answer 33

``` NE-Noradrenaline Epi- adrenaline Adrenal gland (ACH for sweat glands) VAMPS and SNAP ```

Question 34

Alpha 1 receptors

Answer 34

post synaptic effector- smooth muscle Ex. alpha agonist= affe t autoreceptor= stop CA influx= DEC NE 1a, b, d

Question 35

Alpha 2 receptors

Answer 35

Adrenergic System (SNS) pre and post synpatic receptors on platelets, smooth muscle 2a, b, c

Question 36

Beta 1 receptor

Answer 36

Adrenergic System (SNS) 65% receptors on Heart, post synaps. cilary body

Question 37

Beta 2

Answer 37

Adrenergic System (SNS) 30% beta 2 post synap- smooth muse and heart, lungs Asthma- Beta 2 agonist anticholinergic= dec secretions d/t asthma/Cholernergic agonist

Question 38

Beta 3

Answer 38

Adrenergic System (SNS) post synap Adipose issue heart and bladder recent

Question 39

Dopamine

Answer 39

Adrenergic System (SNS) D1-5 Brain, renal

Question 40

Adrenergic NTs

Answer 40

NE and Dopamine, (ACH) sweat glands Termination- reuptake, cells, diffusion, Dopamine (Monamine oxidase?) D-hydroxydase to NE NE (via enzymePhenlyethanolamine) to Epinephrine REuptake stops

Question 41

NMJ ACh synthesis

Answer 41

AP arrives at Pre synatpic Open Ca gate CA flow in mobilies Ach storage in vesicle Ach releases bind to post ganglion receptor

Question 42

NMJ synaps terminoation

Answer 42

Acetycholineresas AchE degrade ACH | AchE inhibitor= INCEASE ACH