ANS drugs

Question 1

adrenergic drug:
MOA: inhibit storage in vesicles
inhibit NE and Dopamine response

Answer 1

Reserpine

cant be stored kay naa ngpa Reserve

Question 2

MOA: inhibit release of catecholamines (2) examples

Answer 2

Guanethedine ,Brethylium

when u use adrenaline.. ma Gua imo Breth

Question 3

MOA: stimulate sympathetic response (4) examples

Answer 3

amphetamine, metamphetamine, ephedrine, tyramine

[Amp! Phred Met Tyra]

Question 4

Class?

MOA: Produce sympathetic response by causing an increase in the concentration of NE in the synaptic clef

Answer 4

Indirect-acting sympathomimetics

Question 5

class?

MOA: stimulate directly adrenergic receptors

Answer 5

Direct acting sympathomimetics

Question 6

Catecholamines is degraded by?

Answer 6

COMT

(Catechol-O-methyl transferase, found in the GI)

Question 7

enumerate (2) common metabolite of catecholamines

Answer 7

metanephrine

Vanillyl mandelic acid (VMA)

Question 8

Vanillyl mandelic acid (VMA) is seen in what condition?

Answer 8

Pheochromocytoma

Question 9

enumerate (3) natural catecholamines

Answer 9

Epinephrine
Norepinephrine
Dopamine
[END]

Question 10

decreased catecholamine concentration stimulates (?) receptors?

Answer 10

Beta receptors

Question 11

increased catecholamine concentration stimulates (?) receptors?

Answer 11

alpha receptors

Question 12

Endogenous source of epinephrine, what site?

Answer 12

adrenal medulla

Question 13

Indication: ACLS, anaphylaxis, shock

Answer 13

epinephrine

Question 14

Pivalic ester derivative of epinephrine given as opthalmic drops for glaucoma

Answer 14

Dipivefrin

Question 15

catecholamine affinity with receptor a1 and b1 ( no effect on a2 b2)

Answer 15

norepinephrine

Question 16

first line mgt of septic shock

Answer 16

norepinephrine

Question 17

receptor for vasodilation of renal and splanchnic blood vessels

Answer 17

D1

[D shape like a kidney]

Question 18

receptor for inotropic agent for shock

Answer 18

B1

Question 19

receptor for vasoconstriction

Answer 19

a1

Question 20

selective b1 agonist drug (1)

Answer 20

dobutamine

Question 21

selective b2 agonist drug (rapid and short acting)

Answer 21

fenoterol albuterol salbutamol terbultaline

[FAST]

Question 22

selective a1 agonist drug

Answer 22

phenylephrine, prophylhexedine, oxymetazoline

-ephrine, -edine, -zoline

Question 23

selective a2 agonist drug

useful in HPN mgt

Answer 23

Clonidine, Methyldopa, Guanfancine, Guanbenz

[GMC]

Question 24

Receptor: Suppression of release of norepinephrine (noradrenaline) by negative feedback

Answer 24

A2

Question 25

nonselective B agonist

Answer 25

isoproterenol

Question 26

selective b2 agonist drug ( slow and low acting)

Answer 26

bambuterol, salmeterol | [BS, this is BS gi asthma na ko ang hina ng effect!]

Question 27

indication: 1. bronchial asthma, COPD 2. tocolytic | 3. mgt of hyperkalemia

Answer 27

Selective b2 agonists

Question 28

SE of Selective b2 agonists (3)

Answer 28

hypokalemia muscle tremors tachycardia

Question 29

Clinical use: A2 agonist, local nasal decongestant

Answer 29

Clonidine

Question 30

Clinical use: A2 agonist, mgt of HPN especially among pregnant patients

Answer 30

Methyldopa

Question 31

SE: of methyldopa

Answer 31

(+)COOMB'S TEST(immune mediated hemolytic anemia) hepatotoxicity sedation

Question 32

drug used pre-operatively in patients with pheochromocytoma

Answer 32

Phenoxybenzamine

Question 33

clinical use: drug selective a-1 blockers alternative mgt of hpn

Answer 33

Phentolamine

Question 34

Phentolamine SE

Answer 34

"FIRST DOSE" phenomenon | -orthostatic hypotension

Question 35

Beta blockers known SE

Answer 35

bronchospasm

Question 36

Muscarininc receptor for ciliary muscles, glands

Answer 36

M3

Question 37

Muscarininc receptor for cardiac nerves

Answer 37

M2

Question 38

Muscarininc receptor for nerve endings

Answer 38

M1

Question 39

Nicotinic receptor for ganglia

Answer 39

N1

Question 40

Nicotinic receptor for end plate/ skeletal muscle

Answer 40

N2

Question 41

Direct acting cholinomimetics

Answer 41

``` choline esters (acetylcholine, metacholine) M,N alkaloid (pilocarpine M, muscarine M, nicotine N) ```

Question 42

indirect acting cholinomimetics

Answer 42

alcohol (5-15 mins)short carbametes (30-8hrs) int (Ex. neo/physostigmine) organophosphates (days to mos) long

Question 43

Test tool in diagnosing MG

Answer 43

Edrophoonium (aka Tensilon Test)

Question 44

Mgt of glaucoma

Answer 44

Physostigmin, Echothiopate, Demecarium [glaucoma is in your PEDigree] Carbachol, Pilocarpine [Piloa ang Car kay daot kag mata]

Question 45

Antidote to Curare-like poisoning

Answer 45

Neostigmine | [neo is rare]

Question 46

Antidote to Atropine toxicity

Answer 46

Physostigmine | [tagpila ang atropine? physo ra]

Question 47

Mgt of urinary retention

Answer 47

Betanechol

Question 48

mgt of smoking addiction

Answer 48

lobeline

Question 49

Cholinergic antagonist protype

Answer 49

Atropine

Question 50

Treatment of organophosphate poisoning

Answer 50

atropine and pralidoxime

Question 51

why is atropine given with anti-diarrheal drug like diphenoxylate

Answer 51

to decrease addiction/ dependence

Question 52

nondepolarizing muscle relaxant use to provide rapid, intense short lasting muscular blockade

Answer 52

succinylcholine

Question 53

most serious complication of succinylcholine

Answer 53

hyperkalemia (with resultant cardiac arrest)

Question 54

Short acting nondepolarizing muscle relaxant

Answer 54

succinylcholine mivacurium rocuronium | [suc mi or]

Question 55

intermediate acting nondepolarizing muscle relaxant

Answer 55

vecorunium atracurium | [atrac vecor( vicar means replacement)]

Question 56

long acting nondepolarizing muscle relaxant

Answer 56

pancuronium, pipecoronium, doxacurium | [pan pipe do]

Question 57

choline esters (3)

Answer 57

bethanichol methacholine carbachol | [Beth has Meth in the Car, hint chol]

Question 58

MOA: blocks Nn receptors

Answer 58

Ganglionic blockers

Question 59

Ganglionic blocker, alternative drug of hpn urgency

Answer 59

Trimetophan

Question 60

MOA: nondepolarizing,reversible Nm blockers

Answer 60

neuromuscular blockers (curare derivatives)