ANS Pharm

Question 1

Muscarinic Receptors on the heart
on the CNS
everything else

Answer 1

Heart: M2, Gi
CNS: M1, Gq (and enterics)
Everything Else: M3, Gq

Question 2

Bethanechol

Answer 2

Muscarinic Agonist

• ileus
• urinary retention

Question 3

Methacholine

Answer 3

Muscarinic Agonist

-bronchial hyperreactivity

Question 4

Pilocarpine

Answer 4

Muscarinic Agonist

• glaucoma
• xerostomia

Question 5

Edrophonium

Answer 5

AChase inhibitor

-diagnose myasthenia gravis

Question 6

Physostigmine

Answer 6

AChase inhibitor

• glaucoma
• atropine overdose

Question 7

Neostigmine

Answer 7

AChase inhibitor

-ileus, urinary retention, myasthenia gravis

Question 8

Donepazil/Tacrine

Answer 8

AChase inhibitor

-Alzheimer Disease

Question 9

Pralidoxime

Answer 9

Regenerates AChase

Question 10

Atropine

Answer 10

Muscarinic Antagonist

-SANS effects

Question 11

Tropicamide

Answer 11

Muscarinic Antagonist

-topical pupil dilator

Question 12

Ipratropium

Answer 12

Muscarinic Antagonist

-asthma and COPD

Question 13

Scopolamine

Answer 13

Muscarinic Antagonist

-motion sickness

Question 14

Benztropine/Trihexyphenidyl

Answer 14

Muscarinic Antagonist

-Parkinsonism

Question 15

Location of D1 receptors

Answer 15

Renal Vessels

-vasodilation

Question 16

Phenylephrine

Answer 16

Alpha-1 agonist

-nasal decongestant

Question 17

Methoxamine

Answer 17

Alpha-1 agonist

-paroxysmal atrial tachycardia

Question 18

Clonidine

Answer 18

Alpha-2 agonist

-moderate HTN

Question 19

Methyldopa

Answer 19

Alpha-2 agonist

-pregnancy HTN

Question 20

Isoproterenol

Answer 20

Beta agonist

-bronchospasm, heart block

Question 21

Dobutamine

Answer 21

Beta-1 agonist

-congestive heart failure

Question 22

Salmeterol

Answer 22

Beta-2 agonist

• long term prophylaxis for asthma
• tremors

Question 23

Albuterol

Answer 23

Beta-2 agonist

-asthma attack

Question 24

Ritodrine

Answer 24

Beta-2 agonist

-premature labor (decreased uterine tone)

Question 25

Oxybutynin

Answer 25

Muscarinic Antagonist | -reduce urinary urgency and bladder spasms (mainly in mild cystitis)

Question 26

Amphetamine

Answer 26

Induces central release of DA, NE, 5HT | -used in narcolepsy, ADHD

Question 27

Ephedrine

Answer 27

Nasal decongestant that releases stored catecholamines

Question 28

Phentolamine

Answer 28

Alpha Antagonist | -given to patients on MAOIs who eat tyramine containing food

Question 29

Phenoxybenzamine | toxicity

Answer 29

Alpha Antogonist - Pheochromocytoma (used to reduce catecholamine levels before surgery) - Tox: orthostatic hypotension, reflex tach

Question 30

Prazosin, Terazosin, Doxazosin | toxicity

Answer 30

Alpha-1 Blockers - HTN, urinary retention, BPH - Tox: 1st dose orthostatic hypotension, headaches, dizziness

Question 31

Mirtazapine

Answer 31

Alpha-2 blocker | -depression

Question 32

Name the Beta-1 antagonists (5)

Answer 32

``` Acebultolol Betaxolol Esmolol Atenolol Metoprolol ```

Question 33

Name the 4 non-selective Beta blockers

Answer 33

Propranolol Timolol Nadolol Pindolol

Question 34

Name the two partial beta agonists

Answer 34

Pindolol | Acebutolol

Question 35

Name the 2 beta blockers that also have alpha agonist activity

Answer 35

Carvedilol | Labetolol