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Mini 2 Pharm- JOHN > ANS Pharm > Flashcards

ANS Pharm Flashcards

1
Q

ANS

What is the mechanism of M1 receptors?

A

Gq- EXCITATORY
PLC –> increased IP3/DAG
Closing K+ channels

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2
Q

ANS

What is the M2 receptor mechanism?

A

Gi- INHIBITORY
Decreased cAMP
Open K+ channels

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3
Q

ANS

What is the M3 receptor mechanism?

A

Gq- EXCITATORY

PLC –> increased IP3/DAG

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4
Q

ANS

What is the action of Hemicholinium?

A

Blocks choline uptake

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5
Q

ANS

The action of Vesamicol?

A

Prevents storage of Ach

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6
Q

ANS

Action of Muscarine?

A

receptor activation

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7
Q

ANS

Action of Atropine?

A

receptor blockade

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8
Q

ANS

Action of Nicotine?

A

receptor activation

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9
Q

ANS

Heart cholinergic impulses

A

SA node:
Rhythm decreased-M2
Contractility decreased-M2

AV node:
conduction decreased-M2
Refractoriness increased-M2

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10
Q

ANS

Lung cholinergic impulses

A

Bronchial muscle contraction-M3

Secretions increased-M3

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11
Q

ANS

Penis cholinergic impulses

A

Boner-M3 (via NO)

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12
Q

ANS

Uterus cholinergic impulses

A

variable-M3

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13
Q

ANS

GIT cholinergic impulses

A

Motility increased-M3
Watery secretion from glands-M3
Gallbladder contraction-M3

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14
Q

ANS

Pancreas cholinergic impulses

A

Exocrine secretion increased-M3

Insulin secretion increased-M

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15
Q

ANS

Urinary bladder cholinergic impulses

A

Detrusor contraction-M3

Sphincter relaxation-M2

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16
Q

ANS

Eye cholinergic impulses

A

Sphincter of iris contraction-M3
Ciliary muscle contraction-M3
Lacrimal gland secretion-M3

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17
Q

ANS

Skin cholinergic impulses

A

Sweat gland secretion-M3

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18
Q

ANS

Autonomic nerve endings

Sympathetic

A

Inhibition of NE release-M2

19
Q

ANS

Autonomic nerve endings

Parasympathetic

A

Inhibition of Ach release-M2

20
Q

ANS

What is the mechanism of Alpha-1 receptor?

A

Gq
PLC–> increased IP3/DAG
PLA2–> eicosanoid synthesis

21
Q

ANS

Mechanism of Alpha-2 receptor?

A

Gi- Decreased cAMP
Gi- Opening of K+ channels
Go- Blockade of Ca2+ channels

22
Q

ANS

Mechanism of Beta-1 receptor?

A

Gs
Increased cAMP
Opening Ca2+ channels

23
Q

ANS

Mechanism of Beta-2 receptor?

A

Gs

Increased cAMP

24
Q

ANS

Mechanism of Beta-3 receptor?

A

Gs

Increased cAMP

25
Q

ANS

Mechanism of D-1 receptor?

A

Gs

Increased cAMP

26
Q

ANS

Mechanism of D-2 receptor?

A

Gi- Opening K+ channels

Go- Blockade of Ca2+ channels

27
Q

ANS

Heart adrenergic impulses

A

SA node- rhythm:
Increased rhythm- Beta1

Conduction increased- Beta1
Refractoriness decreased- Beta1
Contractility increased- Beta1
Automaticity increased- Beta1

28
Q

ANS

Arteriole adrenergic impulses

A

Various organs- constriction- Alpha1
Skeletal muscle dilation- Beta2
Liver dilation- Beta2

29
Q

ANS

Vein adrenergic impulses

A

Constriction- Alpha1

Dilation- Beta2

30
Q

ANS

Spleen capsule adrenergic impulses

A

Spleen capsule contraction- Alpha1

31
Q

ANS

Lung adrenergic impulses

A

Bronchial muscle relaxation- Beta2
Secretions decreased- Alpha1
Secretions increased- Beta2

32
Q

ANS

Skin adrenergic impulses

A

Sweat glands- thick secretion- Alpha1

33
Q

ANS

Platelet adrenergic impulses

A

Aggregation- Alpha2

34
Q

ANS

Mast cells, basophils adrenergic impulses

A

Inhibition of degranulation- Beta2

35
Q

ANS

Fat cell adrenergic impulses

A

Increased lipolysis- Beta3

36
Q

ANS

Sex organs adrenergic impulses

A

Ejaculation- Alpha1

Uterus relaxation- Beta2

37
Q

ANS

GIT adrenergic impulses

A

Exocrine glands- thick secretion- Betas

Sphincter contraction- Alpha1

38
Q

ANS

Liver adrenergic impulses

A

Glycogenolysis increased- Beta2

Gluconeogenesis increased- Beta2

39
Q

ANS

Pancreas adrenergic impulses

A

Insulin secretion decreased- Alpha2

Glucagon secretion increased- Beta2

40
Q

ANS

Adrenergic effect on Kidney

A

Increased renin secretion- Beta1

Increased diuresis- D1

41
Q

ANS

Adrenergic effects on Urinary bladder

A

Trigone and sphincter contraction- Alpha1

42
Q

ANS

Adrenergic effects on Eye

A

Radial muscle contraction- Alpha1
Increased aqueous humor- Beta2
Decreased aqueous humor- Alpha2

43
Q

ANS

Adrenergic effects on Skeletal muscle

A

Increased Ca2+ sequestration- Beta2
Increased glycogenolysis- Beta2
Increased K+ uptake- Beta2
Constant activation can cause tremor

44
Q

ANS

Adrenergic effects on Autonomic nerve endings

A

Sympathetic- NE release decreased- Alpha2
NE release increased- Beta2

Parasympathetic- Ach release- Alpha2

Mini 2 Pharm- JOHN (1 decks)

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