ANS physiology Flashcards

1
Q

2 parts of the ANS

A

parasympathetic and sympathetic

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2
Q

exceptions to divide of para and sympathetic

A

○ Salivary glands have both sympathetic and parasympathetic innervation, but both stimulate saliva secretion

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3
Q

organs that don’t receive dual innervation

A

○ Sweat glands receive only sympathetic neurons

○ Blood vessels (arterioles and veins) receive only sympathetic nerve fibres, except penis and clitoris

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4
Q

sympathetic tone

A

§ A baseline firing frequency

§ Vasomotor tone provides partial constriction

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5
Q

The ANS is activated mainly by

A

centres in the spinal cord, brain stem, hypothalamus and portions of the cerebral cortex

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6
Q

Hypothalamus

A

□ Nuclei for primitive functions - hunger, thirst

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7
Q

§ Midbrain, pons, and medulla

A

□ Nuclei for cardiac and vasomotor control, salivation, swallowing, sweating, bladder control, and pupillary changes

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8
Q

§ Spinal cord reflexes

A

□ Defecation and micturition reflexes integrated in cord

□ Brain can inhibit these responses consciously

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9
Q

parasympathetic nerves

A

pre and post ganglionic nerve

ganglion in the effector organ

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10
Q

sympathetic nerves

A

pre and post ganglionic nerve
ganglion in the spinal cord
OR
pre ganglionic goes to adrenal gland and blood stream acts and post ganglionic nerve

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11
Q

where do parasympathetic nerves leave the spinal cord

A

cranio sacral

top and bottom

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12
Q

where do sympathetic nerves leave the spinal cord

A

thoraco lumbar

middle

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13
Q

neuromessenger used by parasympathetic

A

○ Both pre and post ganglionic nerves produce and secrete acetyl choline

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14
Q

neuromessenger used by sympathetic

A

uses acetyl choline but also uses noradrenaline at the post ganglionic nerves

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15
Q

exceptions to neuromessenger used by sympathetic

A

§ Sweat glands
□ Sympathetic nerve but only uses acetyl choline
§ Also neuroendocrine
□ Releases adrenaline into blood stream
□ Blood stream acts as post ganglionic supply

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16
Q

Adrenal medulla

A
  • Composed of modified sympathetic neurons
    • Prolong the fight or flight response
    • Secrete catecholamines
17
Q

catecholamines

A

○ Adrenaline and noradrenaline

18
Q

NANC neurotransmitters

A
  • Non adrenergic, non cholinergic

- Postganglionic neurons

19
Q

noradrenaline in vascular smooth muscle

A

constriction

20
Q

noradrenaline in skeletal muscles

A

relaxation

21
Q

noradrenaline in bronchial smooth muscle

A

relaxation

22
Q

acetylcholine receptors

A

muscarinic and nicotinic (cholinergic receptors)

23
Q

noradrenaline receptors

A

adrengeric

24
Q

adrenaline receptors

A

adrenergic

25
Q

alpha adrenoceptors

A

mostly respond to noradrenaline

smooth muscle constriction

26
Q

beta adrenoceptors

A

mostly respond to adrenaline

smooth muscle relaxation

27
Q

cholinergic receptors

A

nicotinic and muscarinic

28
Q

noradrenaline in heart rate

A
  • Sympathetic releases noradrenaline onto pacemaker cells of heart
    ○ synoatrial node cells
    ○ Binds to beta receptors which opens calcium channels which causes excitatory response
    ○ Heart beast faster
29
Q

acetyl choline in heart rate

A
  • Parasympathetic releases acetyl choline
    ○ Binds to metabotropic/muscarinic receptor
    ○ Opens potassium channel causing hyperpolarisation
    ○ Slows down action potentials to slow heart rates
30
Q

ANS agonists

A

○ Phenylephrine
○ Isoproterenol
○ Sulbutamol

31
Q

ANS Antagonists

A
  • Phentolamine
    • Propranolol
    • Metoprolol
32
Q

Muscarinic antagonists

A
  • Atropine

- Scopolamine

33
Q

Nicotinic antagonists

A
  • Ganglionic blockers
    • Curare
    • Hexamehtonium
34
Q

Anticholinesterases

A
  • Physostigmine - myasthania gravis
    • Insect spray
    • Nerve gases