Anterior pituitary hormones

Question 1

Gonadorelin analogues examples

Answer 1

Triptorelin and Gosorelin

Question 2

Gonadorelin antagonist example

Answer 2

Degarelix

Question 3

Effect of Gonadorelin antagonist/ analogues on hormone levels

Answer 3

Increase in FSH and LH
Initial increase in oestrogen and testosterone hormone levels- these are then downregulated

Question 4

Which anterior pituitary hormone analogue can be used to diagnose adrenal insufficiency?

Answer 4

Tetracoasctide (analogue of ACTH)- if cortisol fails to rise after this is given- indicates adrenal insufficiency

Question 5

Which hormone is used for growth deficiency in children?

Answer 5

Somatrogon (synthetic human growth hormone)

Question 6

Other than growth deficiency, what else can growth hormones be used to treat?

Answer 6

Prader-Willi syndrome, Turner syndrome, chronic renal insufficiency

Question 7

Main side effect of gonadorelin analogues when used in prostate and breast cancer treatment

Answer 7

Tumour flare

Question 8

SEs of gonadorelin analogues/ antagonists

Answer 8

gynaecomastia, sexual dysfunction, hot flushes, HF, depression, alopecia, skin reactions

Question 9

Indications for Gonadorelin analogues

Answer 9

Infertility, endometriosis, prostate and breast cancer