Anterior Uveitis

Question 1

What is uveitis ?

Answer 1

inflammation inside the eye

Question 2

What are the 3 take home messages of uveitis?

Answer 2

• Anterior uveitis is only anterior when posterior
  segment disease has been excluded
• Always check the corrected vision
• Always measure the intraocular pressure

Question 3

How do you classify uveitis?

Answer 3

• Anterior
• Intermediate
• Posterior
• Panuveitis
• acute or chronic –
  lasts less or more
  than 3 months

Question 4

Define acute anterior uveitis?

Answer 4

the most common form of
uveitis. It is inflammation of iris and ciliary body
* often episodic and
recurrent
* wide range of causes
* up to 50% idiopathic
* About 60% associated
with HLA B27

Question 5

What are the symptoms of anterior uveitis?

Answer 5

Acute:
* redness
* pain
* blurred vision
* photophobia

Chronic:
* blurred vision
* none

Question 6

What is HLA-B27?

Answer 6

Human leukocyte antigen B27 (HLA-B27) is a protein located on the surface of your white blood cells. An HLA-B27 test is a blood test that identifies HLA-B27 proteins.
* HLA B27 positive acute anterior
uveitis
– without systemic disease
– Ankylosing spondylitis
– Reiter’s syndrome
– Inflammatory bowel disease
– Psoriasis
* HLA B27 negative acute anterior
uveitis
– systemic disease
– local eye disease /ocular
syndrome
– idiopathic

Question 7

What is Ankylosing spondylitis?

Answer 7

Ankylosing spondylitis (AS) is a long-term condition in which the
spine and other areas of the body become inflamed.
AS tends to first develop in teenagers and young adults. It’s also around 2 times more common in men than in women.

Question 8

What are the different B27 disorders?

Answer 8

AS, reactive arthritis, inflammatory bowel disease, psoriasis

Question 9

What micro-organisms that have been associated with HLA-B27 disease?

Answer 9

• Chlamydia
• Salmonella
• Shigella
• Yersinea
• Campylobacter
• Streptococci

Question 10

What is Juvenile idiopathic Arthritis
associated uveitis?

Answer 10

• WHITE EYE
• Chronic anterior uveitis
• band keratopathy frequent
• Uveitis about 20%
• HLA B27 –ve, ANF +ve
• Screening programme

Question 11

What is Juvenile HLA B27?

Answer 11

• Acute recurrent uveitis RED EYE
• May have hypopyon
• go on to typical
  spondyloarthropathy
• positive family history
• ANA & RF negative
• HLA B27 positive
• uveitis common

Question 12

What are the different health conditions associated with chronic anterior uveitis?

Answer 12

sarcoidosis
Fuchs heterochromic cyclitis
herpes simplex uveitis
varicella zoster uveitis
varicella zoster sine herpete
masquerade syndromes

Question 13

Complications of anterior uveitis?

Answer 13

• posterior synechiae
• elevated intraocular
  pressure
• cataract
• cystoid macular oedema

Question 14

Aims of treatments for anterior uveitis?

Answer 14

• Suppress inflammation
• Alleviate symptoms
• Prevent complications
• Treat complications

Question 15

What are the topical steroids for uveitis?

Answer 15

• Dexamethasone
• Betamethasone
• Prednisolone acetate
• Prednisolone phosphate
• Loteprednol
• Rimexolone
• (Fluoromethalone