Anti-angina drugs

Question 1

Drugs to treat angina:

Answer 1

beta blockers
nitrates
calcium channel blockers
K channel activators

Question 2

short acting nitrate:

Answer 2

glyceryl trinitrate

Question 3

long lasting nitrate:

Answer 3

isosorbide mononitrate

Question 4

how do nitrates increase oxygen supply?

Answer 4

vasodilation of collaterals + reduce ventricular pressure

Question 5

how do nitrates decrease oxygen demand?

Answer 5

reduce afterload and preload

Question 6

nitrate drugs activate which protein by which second messenge

Answer 6

myosin light chain phosphoatease , cGMP

Question 7

verapamil blocks which calcium current?

Answer 7

L-type calcium current

Question 8

how does verapmil reduce oxygen demand

Answer 8

inhibits SA and AV node conductance

Question 9

how does verapmil reduce conductance in the SA and AV node?

Answer 9

inhibits upstroke of pacemaker potential

Question 10

how do cardiac channel blockers increase oxygen supply?

Answer 10

increased time spent in diastole

Question 11

how does cardiac channel blockers reduce oxygen demand?

Answer 11

reduce force and rate of contraction

Question 12

vasculare selective calcium channels cause which vessels to dilate:

Answer 12

venous and coronary

Question 13

by dilating the coronary vessels, how do vasculare selective calcium channel blockers treat angina?

Answer 13

dilating coronary vessels increases oxygen supply

Question 14

by dilating the venous vessels, how do vasculare selective calcium channel blockers treat angina?

Answer 14

increase oxygen perfusion and reduce demand (work)

Question 15

by dilating the arterial vessels, how do vasculare selective calcium channel blockers treat angina?

Answer 15

reduce work and oxygen demand

Question 16

calcium channel blockers inhibit which enzyme?

Answer 16

mypsin light chain kinase

Question 17

how do calcium channel blockers inhinit myosin light chain kinase?

Answer 17

inhibit calcium induced calcium release

Question 18

how do beta blockers treat angina?

Answer 18

increase supply and reduce demand of oxygen

Question 19

how do beta blockers reduce demand of oxygen?

Answer 19

inhibit sympathetic activity
reduces force and rate of contraction
reduces work

Question 20

how do beta blockers increase supply of oxygen?

Answer 20

inhibit sympathetic activity
reduced heart rate
extended diastole
increased filling time

Question 21

how does nicorandil cause vasodilation?

Answer 21

K channels and nitrix oxide

Question 22

how does nicorandil decrease demand

Answer 22

vasodilation of arteries reduces afterload

Question 23

how does nicorandil increase oxygen supply?

Answer 23

vasodilation of coronary arteries

Question 24

nicorandil reduces venous return and preload and therefore reduces…

Answer 24

wall stress and increases sub endo perfusion

Question 25

activation of K channels prevents which channels from opening?

Answer 25

L-type calcium channel

Question 26

how does nicorandil increase NO

Answer 26

nitic oxide donor