Anti-Anxiety Flashcards

1
Q

Which drugs are used to treat Anti-Anxiety?

A
  1. Benzos (SA), (IA), (LA)
  2. Anti-BZ
  3. Buspirone
  4. Hydroxyzine
  5. Antidepressants
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2
Q

What is the DOC for Chronic anxiety?

A

SSRI’s

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3
Q

What are the SA Benzos?

A
  1. Oxazepam
  2. Triazolam
  3. Midazolam
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4
Q

What are the IA Benzos?

A
  1. Alprazolam
  2. Temazepam
  3. Lorazepam
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5
Q

What are the LA Benzos?

A
  1. Diazepam
  2. Flurazepam
  3. Clonazepam
  4. Chlordiazepoxide
  5. Clorazepate
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6
Q

What is the anti-BZ?

A

Flumazenil

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7
Q

What is the MOA of Buspirone?

A

Stimulates Sertatonin 5HT 1A receptors

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8
Q

What is the indication of Buspirone?

A

General anxiety disorder

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9
Q

What is the MOA of hydroxyzine ?

A

Antihistamine and Antiemetic

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10
Q

What is the indication of hydroxyzine?

A

Sedation

*for patients with a history of dependence

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11
Q

Which drug used for anxiety has little habituation?

A

hydroxyzine

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12
Q

Which drug used for anxiety has minimal dependence?

A

Buspirone

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13
Q

Which drug used for anxiety lacks anti-convulsive and muscle relaxation?

A

Buspirone

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14
Q

T or F: Buspirone has a slow onset of action.

A

True

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15
Q

What is the MOA of Flumazenil?

A

Benzodiazepine antagonist

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16
Q

What is the indication of Flumazenil?

A

Rapid reversal of sedation and/or OD

17
Q

What are the adverse effects of Flumazanil?

A

BZ withdrawal

  • rapid onset
  • short duration
  • IV ONLY
18
Q

What is the DOC for infrequent events (flying)?

-also used for difficulty going to sleep

A

Triazolam (SA)

19
Q

What is the DOC for amnesia?

-used as an adjunct to anesthesia for anxiety, amnesia, and sedation

A

Midazolam (SA)

20
Q

Which SA BZ is used for ETOH withdrawal?

A

Oxazepam

21
Q

What is the DOC for Panic attacks?

A

Alprazolam (IA)

22
Q

What drug is used for frequent awakenings?

A

Temazepam (IA)

23
Q

Which drug is used for ETOH withdrawal but also used as an adjunct to anesthesia for anxiety, amnesia, and sedation?

A

Lorazepam (IA)

24
Q

What is the DOC for Severe anxiety disorders, muscle relaxation, and Grand Mal seizures (Status Epilepticus)?

A

Diazepam

25
Q

Which drugs are used for ETOH withdrawal as well as an adjunct to anesthesia for anxiety, amnesia, and sedation?

A
  1. Lorazepam (IA)

2. Diazepam (LA)

26
Q

Which drugs are used as an adjunct to anesthesia for anxiety, amnesia, and sedation?

A
  1. Midazolam (SA)
  2. Lorazepam (IA)
  3. Diazepam (LA)
27
Q

What is the DOC for chronic epilepsy and myoclonic seizures?

A

Clonazepam

28
Q

Which 3 drugs are used for ETOH ONLY?

A
  1. Oxazepam
  2. Chlordiazepoxide
  3. Clorazepate
29
Q

Which LA Bz is used for sleep disorders?

A

Flurazepam

30
Q

What is the MOA of ALL the Benzos?

A

Binds to an allosteric site which increases GABA’s affinity for its receptor

–inhibitory

–Cl- influx causes hyper polarization = decreased neuronal firing

31
Q

What are the adverse effects of ALL the Benzos?

A
  1. Liver disease
  2. NA glaucoma
  3. Hx of substance abuse
  4. ETOH and other CNS depressants
32
Q

T or F: There is rapid tolerance with SA Benzos?

A

True

33
Q

T or F: the tolerance and the dependence is LESS with the IA and LA than with the SA.

A

True

34
Q

What are the 4 common adverse effects of ALL the Benzos?

A
  1. Ataxia
  2. Confusion
  3. Cognitive impairment
  4. Drowsiness

(A, C,C, D)