Anti-arrhthmic drugs

Question 1

Procainamide class and MOA

Answer 1

class 1a: na channel blocker..intermediate kinetics

Question 2

procainamide indications

Answer 2

atrial/ vent arrhythmias

2nd or 3dd choice for vent arrhtymias after MI

Question 3

Procainamide AE

Answer 3

hypotension
torsade de pointes
longerme= lupus

Question 4

Quinidine class and MOA

Answer 4

Class 1A, Na channel blocker, intermediate kinetics

same as procainamide…but worse AE so rarely used…can cause sever hypotension

Question 5

Lidocaine class and MOA

Answer 5

Class 1B… na channel blocker, fast kinetics

Question 6

lidocaine indications

Answer 6

arrhythmias after MI
BEST drug for Vent tachy after MI
cant use prophylactically

Question 7

lidocaine AE

Answer 7

mostly neurologic SE

large doses could cause hypotension

Question 8

Mexiletine class and MOA

Answer 8

class 1b, na channel blocker…same as lidocaine

Question 9

Flecainide class and MOA

Answer 9

class 1C, na channel blocker, slow kindetics

Question 10

Flecainide indications

Answer 10

supraventricular arrhythmias in patients w/ normal hearts

Question 11

flecainide AE

Answer 11

increases mortality in patients with ventricular tachyarrhymias, MI, and ectopy

Question 12

Propafenone class and AE

Answer 12

Class IC, na channel blocker…same as flecainide

Question 13

beta blockers: class and drugs

Answer 13

Class II
nonselective: propranolol
selective (b1): esmolol
additional mech: soltalol (also class III)

Question 14

BB indications

Answer 14

prevent recurrent infarct
exercise induced arrhymias
also for: a fib, flutter, and reentry

Question 15

BB AE

Answer 15

bradycardia, reduced exercise capacity, hpotension, av block
bronchospasm (not as much with selective
HYPOGLYCEMIA MAY BE MASKED IN DIABETICS

Question 16

Amiodarone class and MOA

Answer 16

Class III: blocking K+ current…prolongation of AP duration

Question 17

Amiodarone indications

Answer 17

iv: first choice for out of hospital cardiac arrest…terminate vent tachy or fibrillation
oral: recurrent ventricular tachy or fibrillation resistant to other drugs, also used for a fib

Question 18

Amiodarone AE

Answer 18

Bradycardia/ heart block in pations with node disease
pulm toxicity, thyroid problems
cornea microdeposits (not clinically sig)
photodermatities

Question 19

Dronedarone class and MOA

Answer 19

similar to amiodarone, class III prolongation…but no thyroid/ pulmonary toxicity

Question 20

Dronedarone Indications

Answer 20

A fib/ flutter

Question 21

dronedarone AE

Answer 21

contraindicated in HF

Question 22

Verapamil class and MOA

Answer 22

class IV, Ca+ channel blocker, major effects to av/ sa node, slowing down conduction and automaticity

Question 23

Verapamil indications

Answer 23

1st choice: supraventricular arrhythmias
reentry involving AV node
slow vent rate in A fib/ flutter

Question 24

Verapamil AE and contra

Answer 24

contra: ventricular tachyrcardia (cause hypotension and fib
av block in patients with av disease
heart block in paitents w/ BB

Question 25

Diltiazem MOA and class

Answer 25

class 4 ca channel blocker..same as erapamil

Question 26

Adenosine Moa/ effects

Answer 26

increase K+ conductance and inhibits CA channel...acting on atrial tissues and nodes produces TRANSINET CARDIAC ARREST

Question 27

Adenosine indications

Answer 27

1st choice of CONVERSION OF PAROXYSMAL SUPRAVENTRICLAR TACHYCARDIA

Question 28

Adenosine AE

Answer 28

flushing and shortness of breath, bradycardia, decrease in BP