Anti-cholesterol drugs Flashcards Preview

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Flashcards in Anti-cholesterol drugs Deck (14):
1

Give two examples of statins

Simvastatin and atorvastatin

2

What do statins block

HMG CoA reductase

3

What effect does blocking the HMG CoA reductase have

Reduced LDL production in liver and increased clearance of LDL in the liver

4

What four pathological effects do statins have

Decrease inflammation, reverse endothelial dysfunction, decrease thrombosis and stabilize atherosclerotic plaques

5

Which 6 disease/scenarios are statins used

Hypercholesterolaemia, diabetes, angina, MI, TIA and high risk of CVA

6

Why are statins not used in pregnancy

Cholesterol is needed for foetal development

7

2 side effects of statins

Myopathy and rhabdomyolysis renal failure

8

2 examples of fibrates

Bezafibrate and gemfibrozil

9

What effect do fibrates have

Decrease triglyceride levels and slight decrease in LDL and HDL by decreasing liver's production of the particle carrying them in the blood

10

When are fibrates used

Hypertriglyceridaemia and low HDL cholesterol

11

Side effects in fibrates

May cause myotosis and therefore adviced to use along with statins

12

Examples of bile acid binding resins

colestryamine, colestipol and colsevelam (The cols)

13

What do bile acid binding resins do

Cause the excretion of bile salts, resulting in more cholesterol to be converted to bile salts. This decreases absorption of triglycerided and increased LDL receptor expression (causing increased clearance of LDL)

14

Side effects of bile acid binding resins

G.I. tract infections