Anti Coagulation Flashcards
(43 cards)
Which factors are affected by Heparin?
12, 11, 10, 9, 2A(thrombin)
Which factors are Vit K dependent?
2, 7, 9, 10
What is the prototypical parenteral anticoagulant?
Heparin
What is the prototypical oral anticoagulant?
Warfarin
What is heparins MOA?
Inactivation of clotting factors
What is warfarins MOA?
Decreases synthesis of clotting factors
What is aspirins MOA?
Decrease plateley aggregation
What is Thombolytic drugs prototype?
Streptokinase
What is streptokinases MOA?
Fibrinolysis
What is the effect that differentiates warfarin and heparin from aspirin?
Aspirin prevents arterial thrombus, warfarin and heparin prevent venous thrombosis
What is heparin a mixture of?
Sulfated mucopolysaccharides
How can heparin be administered?
IV or deep SQ
What blood test monitors heparins affects?
PTT
What are the ADEs for heparin
Hemorrhage
HIT
Osteoperosis
Mineralcorticoid deficiency
What is heparins antidote?
Protamine sulfate
Whats the in depth heparin HMW MOA?
Enhances the action of antithrombin III
inhibits IIa, 9, 10, 11, 12
Binds to AT-III and causes a conformational change
What is the in depth heparin LMWH MOA?
Mainly inhibits factor 10
What do heparins not affect?
Thrombin bound to fibrin or Xa bound to platelets
Can you use heparin in pregnant patients?
Yes
What is the alternative anticoagulant to switch to in the case of HIT?
Lepirudin or danaparoid
What drug increases warfarin activity through inhibiting S warfarin and displace albumin bound warfarin?
Sulfinpyrazone
What decreases warfarin activity?
Barbs, phenytoin, Vit K, and Chole’s
What is the oral direct factor X inhibitor?
Rivaroxaban (Xarelto)
What are the properties to know about rivaroxaban?
Does not require monitoring and has rapid onset of action
