Anti-Depressants- SSRI/SNRI Flashcards
(15 cards)
Topirimate
Use:
Side Effects:
Topirimate
Use: Anticonvulsant used in migraine prophylaxis and/or mood stabilization (impulse disorders)
Side Effects: Weight loss (hooray!) and cognitive slowing
slowed recall
Fluoxetine (Prozac)
What makes it special?
Fluoxetine (Prozac)
Safe in pregnancy
longest half-life
can elevate levels of antipsychotics leading to increased side effects
Sertraline (Zoloft)
What makes it special?
Sertraline (Zoloft)
sertraline has a higher risk of GI disturbances
very few interactions with other drugs
Paroxetine (Paxil)
What makes it special?
Paroxetine has several drug interactions
side effects include anticholinergic effects (sedation, constipation, weight gain)
The short half-life can lead to withdrawal phenomena
Fluvoxamine (Luvox)
What makes it special?
Fluvoxamine is only approved to treat OCD (even tho its an SSRI)
CYP inhibitor so lots of drug interactions
Citalopram (Celexa)
What makes it special?
Citalopram has the fewest drug-drug interactions
watch out for the dose dependent QTc prolongation
Escitalopram (Lexipro)
What makes it special?
Escitalopram is the levo-enantiomer of citalopram so it has fewer side effects than citalopram.
Like Citalopram, it has a dose dependent QTc prolongation
SSRI:
Use:
Side Effects:
SSRI’s inhibit presynaptic serotonin uptake leading to an increase in serotonin in the synaptic cleft.
Use: Depression, OCD,
Side Effects: N/D, sleep disturbances (insomnia or vivid nightmares), headache, weight loss, sexual dysfunction, restlessness, SEROTONIN SYNDROME
Serotonin Syndrome
Serotonin Syndrome:
Fever, diaphoresis, tachycardia, hypertension, delirium, neuromuscular excitability (hyperreflexia)
SNRI
Use:
Side Effects:
SNRI’s inhibit the reuptake of both serotonin and norepinephrine
Use: depression, anxiety, neuropathic pain, PTSD
Side effects are similar to SSRI’s
Venlafaxine (effexor)
what makes it special?
Venlafaxine
higher doses can cause increased blood pressure
other side effects are similar to SSRI’s
Duloxetine (Cymbalta)
What makes it special?
Duloxetine is often used to treat depression, neuropathic pain, or fibromyalgia
Side effects: constipation and dry mouth
can cause hepatotoxicity
Buproprion (Wellbutrin)
What makes it special?
Buproprion is a norepinephrine-Dopamine reuptake inhibitor.
It has fewer sexual side effects
Smoking Cessation
can cause increased anxiety, seizures, and psychosis at high doses
contra indicated in patients with active eating or seizure disorders, patients taking an MAOI, and
Trazadone
What makes it special?
Use Trazadone in folks who need help sleeping
can cause priapism
Mirtazapine (Remeron)
Mirtazapine
a2-Adrenergic receptor antagonist
use in patients with major depression
Side Effects: weight gain and sedation
