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PR3151 > Anti-fungal Agents > Flashcards

Anti-fungal Agents Flashcards

1
Q

What antifungals are used in subcutaneous and systemic mycotic infections?

A
  1. Polyenes: Amphotericin B
  2. Antimetabolite antifungal: Flucytosine
  3. Echinocandins: Caspofungin
  4. Azole: triazoles
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2
Q

What antifungals are used in cutaneous mycotic infections?

A
  1. Polyenes: Nyastatin
  2. Squalene epoxidase inhibitors: Terbinafine
  3. Azole: Imidazoles
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3
Q

How does polyenes work?

A

Bind to ergosterol on fungi cell wall and create pores, leading to leakage of intracellular materials

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4
Q

Amphotericin B iso coformulated with

A

Deoxycholate (liposomal prep)

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5
Q

Does Amphotericin B have good CSF pebetration?

A

No

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6
Q

Clearance of Amphotericin B

A

Renal

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7
Q

ADR of Amphotericin B

A
  1. Fever and chills
  2. Nephrotoxicity- hydrate adequately
  3. Electrolyte imbalances, hypotension
  4. Thrombophlebitis - add heparin
  5. BM suppression
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8
Q

MOA of echinocandins

A

Inhibit activity of glucan synthase complex, loss of cell wall integrity

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9
Q

Name 2 echinocandins

A
  1. Micafungin
  2. Anidulafungin
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10
Q

Administration of echinocandins

A

Parental

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11
Q

Azoles MOA

A

Inihibit C14 alpha demethylase, blocking demethylation of lanosterol to ergosterol
ergosterol biosynthesis inhibition disrupts membrane function and structure, inhibit growth

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12
Q

Name 3 triazoles

A
  1. Fluconazole
  2. Posaconazole
  3. Itraconazole
  4. Voriconazole
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13
Q

CI Azoles

A

DDI - INHIBIT CYP450 3A4
- preg

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14
Q

Name 2 imidazole

A
  1. Clotrimazole
  2. Miconazole
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15
Q

Is nystatin topical or systemic

A

Topical

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16
Q

What can be used for oropharyngeal candidiasis?

A

Nystatin (thrust)

17
Q

MOA terbinafine

A

Inhibit squalene epoxidase inhibitor, blocking squalene conversion to lansterol

18
Q

What can be used against trichophyton?

A

Terbinafine

PR3151 (12 decks)

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