Anti-infective Spectrum of activity - 10Qs

Question 1

List the B-lactam that attack cell walls.

Answer 1

Penicillins
Cephalosporin
Carbapenems
Monobactams

ALL of them

Question 2

List the Glycopeptides that attack cell walls.

Answer 2

Vancomycin

Telavancin

Question 3

List the AB that attack cell membranes.

Answer 3

Daptomycin

Colisitin

Question 4

List the ABs that attack 30s ribosome (Cytoplasm)

Answer 4

Tetracycline e.g. minocycline, doxycycline

Aminoglycosides e.g. Amikacin, tobramycin, gentamicin

Glycyclines e.g. Tigecycline

Question 5

List the ABs that attack 50s ribosome (Cytoplasm)

Answer 5

Macrolides
Clindamycin
Quinopristin/Dalfopristin

Question 6

List the ABs that attack 50s/Initiation complex ribosome (Cytoplasm)/ 23s subunits of 50s

Answer 6

Linezolid

Question 7

List the ABs that attack DNA synthesis

Answer 7

Fluoroquinolones
Metronidazole
Trimethoprim/Sulfamethoxazole
Rifampicin

Question 8

List the penicillins that are ANTIPSEUDOMONAS

Answer 8

Piperacillin

Ticarcillin

Question 9

List the Cephalosporin that are ANTIPSEUDOMONAS

Answer 9

Ceftazidime
Cefepime
Ceftaroline

Question 10

List the Carbapenems that are ANTIPSEUDOMONAS

Answer 10

Doripenem
Imipenem-cilistatin
Meropenem

Question 11

List the Fluoroquinolones that are ANTIPSEUDOMONAS

Answer 11

Ciprofloxacin

Levofloxacin

Question 12

List the Aminoglycosides that are ANTIPSEUDOMONAS

Answer 12

Amikacin

Tobramycin

Question 13

List other AB that are ANTIPSEUDOMONAS

Answer 13

Aztreonam

Colisitin

Question 14

List ABs that are active against MRSA

Answer 14

IV Ceftaroline (Cephalosporin-B-lactam)
Sulfonamides (active against some strains of MRSA (CA-MRSA))
Vancomycin (Glycopeptides)
Linezolid
Daptomycin (cyclic Lipopeptides)

Question 15

Which B-lactam is the exception to the short t1/2 of this group?

Answer 15

Ceftriaxone

Ertapenem

Question 16

Which B-lactam is the exception to this Grp being primarily renally cleared?

Answer 16

Nafcillin
Oxacillin
Ceftriaxone

Question 17

List ABs that are responsible for Above Diaphragm bugs (Anaerobes)

Answer 17

Natural Penicillins e.g. Pencillin G and V
Extended spectrum Penicillins e.g. Piperacillin and Ticarcillin
Lincosamides e.g. Clindamycin

Question 18

List drug of choice for MSSA

Answer 18

Nafcillin
Oxacillin
Cefazolin IV

Question 19

List ABs that are responsible for Below Diaphragm bugs (Anaerobes)

Answer 19

Metronidazole

Question 20

Which AB is both bacterioSTATIC and bacteriCIDAL

Answer 20

Oxazolidinones
Streptogramins
Chloramphenicol

Question 21

For the B-lactams, what’s the relationship btw MIC dependent killing and Time?

Answer 21

Time>MIC dependent killing

Question 22

Which AB is effective against Listeria?

Answer 22

Ampicillin

Sulfonamides

Question 23

List common gram tve m.o.

Answer 23

Staphylococcus
Streptococcus
Enterococcus

Question 24

List common gram -ve m.o.

Answer 24

Haemophilus
E. coli
Neisseria
Proteus
Pseudomonas 
E
Kelbsiella
Moraxella

HENPEKM

Question 25

What AB covers coagulase negative staph?

Answer 25

Glycopeptides e.g. Vancomycin

Question 26

Which ABs have a broad coverage against anaerobes?

Answer 26

Amoxicillin/Clavulanate PO Piperacillin/Tazobactam (Zosyn) IV Moxifloxacin (Fluoroquinolones) Lincosamides

Question 27

What AB may cuz bone marrow suppression and serotonin syndrome (if used with MAO active drugs)?

Answer 27

Oxazolidinones e.g. Linezolid

Question 28

What ABs is effective against VRE?

Answer 28

Oxazolidinones e.g. Linezolid Cyclic Lipopeptides e.g. Daptomycin

Question 29

What ABs are effective against Pseudomonas and Acinetobactor?

Answer 29

Ceftazidime Piperacillin

Question 30

What AB req central line access for administration?

Answer 30

Streptogramins e.g. Quinopristin+Dalfopristin

Question 31

What AB req regular CPK monitoring at baseline and weekly thereafter?

Answer 31

Cyclic lipoprotein e.g. Daptomycin

Question 32

What's unique about Amikacin activity?

Answer 32

Mycobacterium activity

Question 33

What's the 2nd line for TB?

Answer 33

Streptomycin

Question 34

What ABs req Therapeutic Drug Monitoring (TDM)?

Answer 34

Aminoglycosides e.g. Gentamicin | Glycopeptides e.g. Vancomycin

Question 35

Why's Polymixin not 1st line?

Answer 35

About 30% of pts develop nephrotoxicity

Question 36

What's the drug of choice for mild to moderate C.Diff?

Answer 36

Metronidazole

Question 37

What PROTOZOAN is susceptible to metronidazole?

Answer 37

Giardia lambia Gardinerella vaginalis Entamoeba Histolytica GET

Question 38

What AB has a metallic taste as a SE?

Answer 38

Metronidazole

Question 39

List atypical m.o. Covered byFluroquinolones

Answer 39

Mycoplasma Legionella Chlamydia Myocobacteria including TB

Question 40

What ABs cover atypical m.o.?

Answer 40

Fluoroquinolones e.g Ciprofloxacin, Sulfonamide Macrolide e.g. Azithromycin, Clarithromycin,

Question 41

What AB may suppress bone marrow suppression and may be a concern in Immunosuppressed pt, cancer pt etc

Answer 41

Sulfonamides e.g. Sulfamethoxazole, Trimethoprim

Question 42

What AB has coverage over Enterococcus?

Answer 42

Vancomycin Tigecycline Aminoglycosides Fluoroquinolones

Question 43

What AB are active against VRE + ALL Enterococcus?

Answer 43

Streptogramins Tigecycline Daptomycin Oxazolidinones - Linezolid

Question 44

What AB are active against MRSA?

Answer 44

``` Ceftaroline Vancomycin Tigacycline Oxazolidinones Daptomycin Streptogramniss ```

Question 45

What AB are effective against gram tv only?

Answer 45

Glycopeptides e.g. Vancomycin Oxazolifdinones e.g. Linezolid Lipoprotein e.g. Daptomycin Streptogramniss

Question 46

What AB are effective against gram -ve only?

Answer 46

Monobactam e.g. Aztreonam Aminoglycosides PolymixIns B + E

Question 47

What AB may cuz blood dyscrasias?

Answer 47

Chloramphenicol Trimethoprim