Anti-inflammatories Flashcards by Ryker Saunders

Q

Vasodilation mediators that can be affected by drugs:

A

PGs, I2, E1, E2, D2

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Q

Increased Vascular Permeability mediators that can be affected by drugs:

A

Histamine, LTs, C4, D4, E4, and CGRP

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Q

Fever mediators that can be affected by drugs:

A

IL-1, IL-6, TNF, PGE2, PGI2, LTB4, LXA4, LXB4

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Q

Pain mediators that can be affected by drugs:

A

PGE2, PGI2, LTB4, CGRP

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Q

What causes initial bronchospasm and release of inflammatory mediators in asthma?

A

Histamine

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Q

How do antihistamines work?

A

They block effects of histamine binding to H1 receptors, but do not block them from their release from mast cells

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Q

What inflammatory mediators are released by histamine?

A

PGs, LTs, Platelet Activating Factor (PAF), Eosinophil Cationic Protein (ECP), Major Basic Protein (MBP), and proteases

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Q

What type of drug has this mechanism:

Transcriptional regulation inhibitor

A

Corticosteroids

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Q

What type of drug has this mechanism:

Synthesis inhibitors

A

NSAIDs, Zileuton

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Q

What type of drug has this mechanism:

Soluble Cytokine Receptor

A

Certolizumab, Adalimumab

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Q

What type of drug has this mechanism:

Blocking monoclonal antibody

A

Certolizumab, Adalimumab

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Q

What type of drug has this mechanism:

Receptor blockers

A

Antihistamines, Montelukast

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Q

What drug is a(n) inhaled corticosteroid

A

Beclomethasone

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Q

What drug is a(n) oral corticosteroid

A

Prednisone

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Q

What drug is a(n) Leukotriene Receptor Blocker

A

Montelukast

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Q

What drug is a(n) Leukotriene Synthesis Blocker

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A

ZIleuton

Q

What drug is a(n) IgE-Antibody

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A

Omalizumab

Q

What drug is a(n) PDE4 Inhibitor

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A

Roflumilast

Q

What is an NSAID derived from salicylic acid?

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A

Acetylsalicyclic Acid (Aspirin)

Q

What is an NSAID derived from Non-Selective COX inhibitor?

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A

Ibuprofen, Indomethacin, Naproxen

Q

What is an NSAIDthat is a COX-2 specific inhibitor?

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A

Celecoxib

Q

What is an analgesic, antipyretic NSAID?

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A

Acetaminophen

Q

What drug is an anti-IgE antibody and what is its MOA?

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A

Omalizumab, reduces likelihood of histamine release. The mast cells release histamine but the antibody does not receive the signal.

Q

What are the 1st generation antihistamines?

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A

Diphenhydramine, Chlorpheniramine, Dimenhydrinate, and Promethazine (can access the BBB)

What are the 2nd generation antihistamines?

Cetirizine, Fexofenadine, Loratadine

What drug treats COPD and what is its MOA?

Roflumilast, selectively inhibits PDE4

What are the TNF-alpha inhibitor drugs?

Etancercept, Infliximab, Adalimumab, Certolizumab Pegol

Which of the TNF-alpha drugs is not a monoclonal antibody?

Etancercept