Anti-inflammatory/DMARDS/Gout Flashcards
(48 cards)
What is the first prostaglandin formed in the COX pathway
PGG
What prostaglandins are vasodilators
PGE, PGI
What is the end product of the LOX pathway and what do they do
Leukotrienes: bronchoconstriction, bronchial edema, bronchial secretions
What do epoxides do
Inc oxidative stress in cardiac myocytes and renal tubules
What dos COX1 do
Protect gastric mucosa, platelet aggregation,inc renal perfusion
What COX enzyme is inducible in injury
COX2
What drug inhibits COX3
Paracetamol
COX inhibitors ending in coxib are
Selective
ADR of nonseletive cox inhibitors
Gastric irritation, bleeding, AKI
What is the only irreversible cox inhibitor and why
Aspirin - forms covalent bonds
What nonselective cox inhibitors are propionic acid derivatives
Ibuprofen, ketoprofen, flurbiprofen
What drug should not be given with ibuprofen
Aspirin
ADR of flurbiprofen
MI, severe gastric irritation
What is the only non acid derived NSAID
Nabumetone
ADR of sulindac
SJS
How does indomethacin cause decrease in vasodilation
Inhibits phospholipase A2 - dec production of prostaglandins
What NSAID is used in closure of PDA
Indomethacin
Why are lumiracoxib, valdecoxib, and rofecoxib phased out
Causes MI and HPN, ADR is thrombosis
What arthritis is characterized by morning stiffness
Rheumatoid arthritis
Arthritis with osteophyte formation
Osteoarthritis
What causes pannus formation in RA
Chemotaxis of immune complexes
Primary joints affected in osteoarthritis
Distal interphalangeal, carpometacarpal
What arthritis has heberden’s nodes and where are they usually located
Osteoarthritis, in distal phalangeal joints
What drugs address the root cause of RA
DMARDS
