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Pharmacology #1 > Anti-influenza Agents > Flashcards

Anti-influenza Agents Flashcards

1
Q

Influ viruses are classified based on…

A

core protein (A, B, C, etc), species of origin, geographic site

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2
Q

Influ B only infects…

A

humans

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3
Q

What influ virus causes pandemic?

A

Virus A

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4
Q

Influ classified based on surface antigen variants:

A

hemagglutinin (H) and neuraminidase (N)

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5
Q

What virus is endemic in SE Asia Poultry since 2003?

A

H5N1 bird virus

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6
Q

Swine flue pandemic caused by

A

H1N1

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7
Q

Amantadine & Rimantadine (aman derivative) MOA:

A

block M2 proton ion channel of the virus particle and prevent uncoating of the viral RNA within infected cells

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8
Q

Amantadine & RImantadine are only active against….

A

Influ A

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9
Q

Amantadine AE:

A

crosses the BBB, so CNS toxicity (nevousness, difficulty concentrating, insomnia)

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10
Q

Amantadine CNS effects may have to do with…

A

dopamine neurotransmission

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11
Q

Zanamivir & Osteltamivir are both

A

neuraminidase inhibitors and analogs of sialic acid (neuraminia acid)

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12
Q

Zanamivir & Osteltamivir MOA:

A

interfere with the release of progeny influenza viral particles from infected cells

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13
Q

Zanamivir & Osteltamivir are active against:

A

Both Influ A & B

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14
Q

Zanamivir & Osteltamivir administration…

A

early admin is CRUCIAL, within 36-48 hours

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15
Q

Prophylaxis of influ A & B?

A

Zanamivir & Osteltamivir

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16
Q

How is zanamivir admin’d?

A

Nasally or via inhalation

17
Q

How is oseltmavir admin’d?

A

orally, bc its a prodrug

18
Q

INF-a could also be used for treatment of…

A

condyloma acuminatum caused by HPV

19
Q

RIbavirin can also treat…

A

respitory syncytial virus (RSV) in children via aerosol

20
Q

Palivizumab can also be used to treat…

A

RSV (humanized monoclonal Ab)

21
Q

Imiquimod can be used to treat…

A

HPV induced external genital and perianal condyloma acuminatum (warts)

Pharmacology #1 (15 decks)

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